FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022110535> ?p ?o ?g. }

• W2022110535 endingPage "22756" @default.
• W2022110535 startingPage "22743" @default.
• W2022110535 abstract "KCNK10, a member of tandem pore domain potassium channel family, gives rise to leak K+ currents. It plays important roles in stabilizing the negative resting membrane potential and in counterbalancing depolarization. We previously demonstrated that kcnk10 expression is quickly elevated during the early stage of adipogenesis of 3T3-L1 cells and that reduction of kcnk10 expression inhibits adipocyte differentiation. However, the molecular mechanism of KCNK10 in adipocyte differentiation remains unclear. Here we revealed that kcnk10 is induced by 3-isobutyl-1-methylxanthine, a cyclic nucleotide phosphodiesterase inhibitor and a potent inducer of adipogenesis, during the early stage of adipocyte differentiation. We also demonstrated that KCNK10 functions as a positive regulator of mitotic clonal expansion (MCE), a necessary process for terminal differentiation. The reduction of kcnk10 expression repressed the expression levels of CCAAT/enhancer-binding protein β (C/EBPβ) and C/EBPδ as well as the phosphorylation level of Akt during the early phase of adipogenesis. In addition, knockdown of kcnk10 expression suppressed insulin-induced Akt phosphorylation. These results indicate that KCNK10 contributes to the regulation of MCE through the control of C/EBPβ and C/EBPδ expression and insulin signaling." @default.
• W2022110535 created "2016-06-24" @default.
• W2022110535 creator A5000155698 @default.
• W2022110535 creator A5015841809 @default.
• W2022110535 creator A5032291031 @default.
• W2022110535 creator A5042240148 @default.
• W2022110535 creator A5061627489 @default.
• W2022110535 date "2014-12-09" @default.
• W2022110535 modified "2023-10-16" @default.
• W2022110535 title "KCNK10, a Tandem Pore Domain Potassium Channel, Is a Regulator of Mitotic Clonal Expansion during the Early Stage of Adipocyte Differentiation" @default.
• W2022110535 cites W1768275056 @default.
• W2022110535 cites W1970471141 @default.
• W2022110535 cites W1973272114 @default.
• W2022110535 cites W1986439675 @default.
• W2022110535 cites W1988423541 @default.
• W2022110535 cites W1997490378 @default.
• W2022110535 cites W2023809428 @default.
• W2022110535 cites W2037941417 @default.
• W2022110535 cites W2039346654 @default.
• W2022110535 cites W2041895698 @default.
• W2022110535 cites W2044265925 @default.
• W2022110535 cites W2047842452 @default.
• W2022110535 cites W2050703693 @default.
• W2022110535 cites W2064572662 @default.
• W2022110535 cites W2065903312 @default.
• W2022110535 cites W2069443955 @default.
• W2022110535 cites W2070021885 @default.
• W2022110535 cites W2070830713 @default.
• W2022110535 cites W2078178452 @default.
• W2022110535 cites W2080395830 @default.
• W2022110535 cites W2082406934 @default.
• W2022110535 cites W2085439793 @default.
• W2022110535 cites W2085952650 @default.
• W2022110535 cites W2087390102 @default.
• W2022110535 cites W2087775278 @default.
• W2022110535 cites W2091140665 @default.
• W2022110535 cites W2104085328 @default.
• W2022110535 cites W2109566757 @default.
• W2022110535 cites W2110083175 @default.
• W2022110535 cites W2130166672 @default.
• W2022110535 cites W2131597783 @default.
• W2022110535 cites W2150051345 @default.
• W2022110535 doi "https://doi.org/10.3390/ijms151222743" @default.
• W2022110535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4284734" @default.
• W2022110535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25501330" @default.
• W2022110535 hasPublicationYear "2014" @default.
• W2022110535 type Work @default.
• W2022110535 sameAs 2022110535 @default.
• W2022110535 citedByCount "9" @default.
• W2022110535 countsByYear W20221105352016 @default.
• W2022110535 countsByYear W20221105352017 @default.
• W2022110535 countsByYear W20221105352019 @default.
• W2022110535 countsByYear W20221105352021 @default.
• W2022110535 countsByYear W20221105352022 @default.
• W2022110535 crossrefType "journal-article" @default.
• W2022110535 hasAuthorship W2022110535A5000155698 @default.
• W2022110535 hasAuthorship W2022110535A5015841809 @default.
• W2022110535 hasAuthorship W2022110535A5032291031 @default.
• W2022110535 hasAuthorship W2022110535A5042240148 @default.
• W2022110535 hasAuthorship W2022110535A5061627489 @default.
• W2022110535 hasBestOaLocation W20221105351 @default.
• W2022110535 hasConcept C104317684 @default.
• W2022110535 hasConcept C11960822 @default.
• W2022110535 hasConcept C122927707 @default.
• W2022110535 hasConcept C134018914 @default.
• W2022110535 hasConcept C142536801 @default.
• W2022110535 hasConcept C148738053 @default.
• W2022110535 hasConcept C171089720 @default.
• W2022110535 hasConcept C173396325 @default.
• W2022110535 hasConcept C185592680 @default.
• W2022110535 hasConcept C198826908 @default.
• W2022110535 hasConcept C2776175234 @default.
• W2022110535 hasConcept C55493867 @default.
• W2022110535 hasConcept C6929976 @default.
• W2022110535 hasConcept C75217442 @default.
• W2022110535 hasConcept C83743174 @default.
• W2022110535 hasConcept C86803240 @default.
• W2022110535 hasConcept C95444343 @default.
• W2022110535 hasConceptScore W2022110535C104317684 @default.
• W2022110535 hasConceptScore W2022110535C11960822 @default.
• W2022110535 hasConceptScore W2022110535C122927707 @default.
• W2022110535 hasConceptScore W2022110535C134018914 @default.
• W2022110535 hasConceptScore W2022110535C142536801 @default.
• W2022110535 hasConceptScore W2022110535C148738053 @default.
• W2022110535 hasConceptScore W2022110535C171089720 @default.
• W2022110535 hasConceptScore W2022110535C173396325 @default.
• W2022110535 hasConceptScore W2022110535C185592680 @default.
• W2022110535 hasConceptScore W2022110535C198826908 @default.
• W2022110535 hasConceptScore W2022110535C2776175234 @default.
• W2022110535 hasConceptScore W2022110535C55493867 @default.
• W2022110535 hasConceptScore W2022110535C6929976 @default.
• W2022110535 hasConceptScore W2022110535C75217442 @default.
• W2022110535 hasConceptScore W2022110535C83743174 @default.
• W2022110535 hasConceptScore W2022110535C86803240 @default.
• W2022110535 hasConceptScore W2022110535C95444343 @default.
• W2022110535 hasIssue "12" @default.
• W2022110535 hasLocation W20221105351 @default.
• W2022110535 hasLocation W20221105352 @default.

• next