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- W2022110636 abstract "This study investigates the contribution of prostaglandins (PG) and calcitonin gene-related peptide (CGRP) pathways in visceral pain induced by peritoneal irritation in rats. Peritoneal irritation was produced by i.p. administration of acetic acid (AA: 0.06–1.0%, 10 ml/kg). Visceral pain was scored by counting abdominal contractions. The effect of CGRP (3–100 μg/kg, i.p.) was also evaluated. Like AA, CGRP induced abdominal pain. Neonatal pretreatment with capsaicin reduced abdominal contractions produced by AA (0.6%) and CGRP (20 μg/kg) with 64.6% and 45.6%, respectively. Abdominal contractions induced by AA and CGRP were blocked by two antinociceptive drugs, μ-and κ-opioid agonists, morphine and (±)-U-50,488H, respectively. Indomethacin (3 mg/kg, s.c.) reduced the number of abdominal contractions produced by AA by 78.1%±6.4% but did not inhibit abdominal contractions produced by CGRP. The CGRP1 receptor antagonist, hCGRP8–37 (300 μg/kg, i.v.) inhibited AA- and CGRP-induced abdominal contractions with 57.5%±12.4% and 51.6%±11.3%, respectively. Concomitant i.p. administration of PGE1 and PGE2 (0.3 mg/kg of each) produced abdominal contractions which were inhibited 45.6%±9.3% by hCGRP8–37 (300 μg/kg i.v.). Taken together, these results suggest that peritoneal irritation is likely to trigger the release of prostaglandins, which in turn produces a release of CGRP from primary sensory afferents." @default.
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- W2022110636 date "1997-05-01" @default.
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- W2022110636 title "Involvement of prostaglandins and CGRP-dependent sensory afferents in peritoneal irritation-induced visceral pain" @default.
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- W2022110636 doi "https://doi.org/10.1016/s0167-0115(97)02141-1" @default.
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