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• W2022111909 endingPage "146" @default.
• W2022111909 startingPage "138" @default.
• W2022111909 abstract "We have assessed the effectiveness of transplanted histocompatible fibroblasts as a long-lived source of lysosomal enzymes for replacement therapy in three patients with Hunter's syndrome, over periods ranging from 2.5 to 3.75 yr. The level of Hunter corrective factor excreted by all three patients increased after transplantation, as did the activity of alpha-L-idurono-2-sulfate sulfatase in serum, when measured directly with a radioactive disulfated disaccharide substrate. Sulfatase activity was also raised in leukocyte homogenates from the two patients that we were able to assess. These increases in enzyme activity were accompanied by corresponding increases in catabolism of heparan and dermatan sulfates, as shown by (a) a decrease in sulfate:uronic ratios of urinary oligosaccharides, (b) an increase in iduronic acid monosaccharide, and (c) a normalization of Bio-Gel P-2 gel filtration profiles. Both the increase in enzyme activity and increased catabolism were maintained during the period of study and were not affected by either a gradual decrease or total withdrawal of immunosuppressive therapy." @default.
• W2022111909 created "2016-06-24" @default.
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• W2022111909 date "1979-01-01" @default.
• W2022111909 modified "2023-09-26" @default.
• W2022111909 title "Enzyme replacement therapy by fibroblast transplantation: long-term biochemical study in three cases of Hunter's syndrome." @default.
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• W2022111909 doi "https://doi.org/10.1172/jci109267" @default.
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