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- W2022113992 abstract "Standard tests for liver damage testing in sheep include glutamate dehydrogenase, aminotransferases and lactate dehydrogenase. The first is a mitochondrial enzyme which is fairly liver specific, while the others lack organ specificity. Glutathione S-transferase (GST, EC 2.5.1.18) is a cytosolic enzyme which has a high activity in hepatocytes and is thus a candidate enzyme marker of liver damage. An automated procedure based on the conjugation of 1 -chloro-2,4_dinitrobenzene was adapted on a centrifugal analyser and validated for sheep plasma. The limit of quantification was about 0.5 U I-’ and the coefficient of variation of between-series reproducibility was less than 4%. Reference values did not differ according to breed, sex or age (n = 139; nine males, 100 females, 30 undetermined; 127 Lacaune and 12 Manech sheep; 41 animals 3-9 months of age, 98 animals 2-6 years of age). The distribution was log-normal and the median and geometric means were 5.1 U I-’ and 10.0 U I-‘, respectively. The 0.025 and 0.975 quantiles were 2.3 U 1.. ’ and 18.4 U I-‘. Plasma GST showed a circadian rhythm with a minimum (about 60% of maximum) from l7:OO to 05:OO h and was not significantly altered by repeated daily fine needle liver biopsies for 5 days. In experimental liver damage by intraruminal administration of 0.20 ml kg-’ BW CC1 4, plasma GST was increased go-fold in the 24th hour, then returned to baseline by day 4. Thus, plasma GST could be an interesting candidate marker for liver damage testing in sheep." @default.
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- W2022113992 date "1996-06-01" @default.
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- W2022113992 title "Validation of an automated technique for the measurement of glutathione S-transferase in plasma of sheep" @default.
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