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• W2022114931 abstract "Involvement of the Ca2+ ion and membrane potential in the regulation of the Na+-dependent glycine transport was investigated in the Chang liver cell. Depolarization of the cell membrane was associated with the uptake of glycine, showing a half-maximal change in the potential at 1.7 mM of glycine, a value corresponding to the Km for the glycine transport. Addition of EGTA to the assay medium inhibited the glycine uptake in a dose-dependent manner in accordance with the decrease of the intracellular free Ca2+ level and the extent of depolarization of the cell membrane. Trifluoperazine inhibited the glycine uptake with a half-maximal effect at about 16μM, a concentration giv-ing a half-maximum of membrane depolarization. Quinine, a blocker of the Ca2+-dependent K+ channel in liver cells, inhibited the glycine transport and depolarized the cell membrane, depressing K+ release from the cells. The glycine uptake was stimulated by the addition of a calcium ionophore (A23187) to the assay medium, but the uptake was extremely depressed by addition of quinine to the medium or by pretreatment of cells with trifluoperazine, to an extent as low as half of the control. Concomitantly, the K+ release increased by A23187 was depressed in the corresponding ratio by addition of quinine to the medium. These results support the concept that the Na+-dependent glycine transport is regulated by the cytosolic free Ca2+ concentration through the change of the cell membrane potential which is modulated by the activity of the Ca2+-dependent K+ channel requiring calmodulin as a regulator." @default.
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• W2022114931 modified "2023-09-25" @default.
• W2022114931 title "Regulation of the Na+-dependent glycine transport across the plasma membrane by calcium ion and membrane potential." @default.
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• W2022114931 doi "https://doi.org/10.1247/csf.14.447" @default.
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