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- W2022120825 abstract "Prospective, comparative, non-randomized, open, observational study, including 2949 outpatients with schizophrenia who were followed up for 6 months after receiving a new prescription of an antipsychotic. Safety was evaluated collecting adverse events and global clinical status was measured through CGI and GAF Scales. A total of 2128 patients received olanzapine, as monotherapy or in combination (Olanzapine group), and 821 received other antipsychotics (Control group). There were no statistical differences between treatment groups at baseline regarding age, gender, disease duration, severity of symptoms, and EPS. Incidence of adverse events and specifically extrapyramidal symptoms was significantly lower in the olanzapine group compared to the control group (p < 0.001). Mean change in the CGI and the GAF was significantly higher in the olanzapine group compared to the control group (p < 0.001). Despite the limitations of an observational study, these results shows that olanzapine is safe and effective in non-selected schizophrenic outpatients, and are consistent with results of previous controlled trials." @default.
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- W2022120825 date "2000-04-01" @default.
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- W2022120825 title "99. Safety and effectiveness of olanzapine versus other antipsychotic drugs in the treatment of outpatients with schizophrenia" @default.
- W2022120825 doi "https://doi.org/10.1016/s0006-3223(00)00361-9" @default.
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