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- W2022122148 abstract "Experiments were performed to study the effect of verapamil on neuromuscular transmission and muscle contraction at a chick skeletal muscle-nerve preparation. In addition,the effects and interactions of verapamil with some muscle relaxants were studied in the same preparation. These effects were explored by studying the effects of verapamil on: (a) directly-and indirectly-elicited twitch contractions,and (b) neuromuscular blockade produced by gallamine and pancuronium. The results showed that verapamil (2–200 μM) had a differential effect on the twitch responses; more reductions occurred in the indirectly-elicited twitch tension, whereas the directly-elicited twitch response was reduced only by 20–30% of maximum indirectly-elicited twitch tension. Furthermore, in low concentrations (1–20 μM), verapamil significantly increased the neuromuscular blockade produced by gallamine(28–1280 M) and pancuronium(18–573 nM).In high concentrations (> 200 μM),verapamil completely blocked the indirectly-elicited twitch response and produced a marked contracture in the chick skeletal muscle (1.0±0.1 g, n=6). It was concluded that by reducing twitch tension and inhibiting neuromuscular transmission, verapamil increases (intensifies) neuromuscular blockade produced by muscle relaxants, e.g. gallamine and pancuronium." @default.
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- W2022122148 date "1986-06-01" @default.
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- W2022122148 title "Verapamil intensifies neuromuscular blockade produced by gallamine and pancuronium at the chick neuromuscular junction" @default.
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- W2022122148 doi "https://doi.org/10.1016/0031-6989(86)90148-7" @default.
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