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• W2022122616 abstract "We previously reported that a Streptococcus mutans enriched‐glucosytransferase (E‐GTF) preparation induces an immune response following intranasal, but not tonsillar, immunization of humans. In this study, we determined whether intranasal immunization of these subjects 2 years later resulted in augmented immune responses compared to those seen in control subjects. Subjects previously immunized via the intranasal (IN, n = 7) or tonsillar (IT, n = 7) route and control ( n = 12) subjects were immunized via the intranasal route with E‐GTF. Nasal wash, saliva, and serum were collected before immunization and then weekly for 3 months after immunization. Significant ( P < 0.05) mucosal and serum immunoglobulin A (IgA) anti‐E‐GTF responses were observed in all three groups. Nasal and serum IgA anti‐E‐GTF responses were significantly higher ( P < 0.05) in the IN group. The salivary responses in the three groups were, in general, similar. These results indicate that intranasal immunization primes the immune system for a localized secondary response to S. mutans antigens." @default.
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• W2022122616 date "2006-08-21" @default.
• W2022122616 modified "2023-10-11" @default.
• W2022122616 title "Immune response in humans to a nasal boost with Streptococcus mutans antigens" @default.
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• W2022122616 doi "https://doi.org/10.1111/j.1399-302x.2006.00302.x" @default.
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