Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022123095> ?p ?o ?g. }
- W2022123095 endingPage "393" @default.
- W2022123095 startingPage "388" @default.
- W2022123095 abstract "Light-induced phase shifts of circadian rhythmic locomotor activity are associated with the expression of c-Jun, JunB, c-Fos and FosB transcription factors in the rat suprachiasmatic nucleus, as shown in the present study. In order to explore the importance of c-Fos and JunB, the predominantly expressed AP-1 proteins for the phase-shifting effects of light, we blocked the expression of c-Fos and JunB in the suprachiasmatic nucleus of male rats, housed under constant darkness, by intracerebroventricular application of 2 microliters of 1 mM antisense phosphorothioate oligodeoxynucleotides (ASO) specifically directed against c-fos and junB mRNA. A light pulse (300 lux for 1 h) at circadian time 15 induced a significant phase shift (by 125 +/- 15 min) of the circadian locomotor activity rhythm, whereas application of ASO 6 h before the light pulse completely prevented this phase shift. Application of control nonsense oligodeoxynucleotides had no effect. ASO strongly reduced the light-induced expression of c-Fos and JunB proteins. In contrast, light pulses with or without the control nonsense oligodeoxynucleotides evoked strong nuclear c-Fos and JunB immunoreactivity in the rat suprachiasmatic nucleus. These results demonstrate for the first time that inducible transcription factors such as c-Fos and JunB are an essential part of fundamental biological processes in the adult mammalian nervous system, e.g. of light-induced phase shifts of the circadian pacemaker." @default.
- W2022123095 created "2016-06-24" @default.
- W2022123095 creator A5007980662 @default.
- W2022123095 creator A5013363726 @default.
- W2022123095 creator A5027802137 @default.
- W2022123095 creator A5034118095 @default.
- W2022123095 creator A5042898209 @default.
- W2022123095 creator A5043178995 @default.
- W2022123095 creator A5047805663 @default.
- W2022123095 creator A5089627681 @default.
- W2022123095 date "1995-03-01" @default.
- W2022123095 modified "2023-09-25" @default.
- W2022123095 title "Block of c-Fos and JunB Expression by Antisense Oligonucleotides Inhibits Light-induced-Phase Shifts of the Mammalian Circadian Clock" @default.
- W2022123095 cites W1581477122 @default.
- W2022123095 cites W1643735618 @default.
- W2022123095 cites W1729038851 @default.
- W2022123095 cites W1760280961 @default.
- W2022123095 cites W1843131799 @default.
- W2022123095 cites W1869555064 @default.
- W2022123095 cites W1871934956 @default.
- W2022123095 cites W1884284628 @default.
- W2022123095 cites W1967739579 @default.
- W2022123095 cites W1969653160 @default.
- W2022123095 cites W1975146102 @default.
- W2022123095 cites W1985603777 @default.
- W2022123095 cites W1987621988 @default.
- W2022123095 cites W1988369548 @default.
- W2022123095 cites W1991717598 @default.
- W2022123095 cites W1993785975 @default.
- W2022123095 cites W1996814895 @default.
- W2022123095 cites W1998448534 @default.
- W2022123095 cites W2006164228 @default.
- W2022123095 cites W2008388867 @default.
- W2022123095 cites W2009841380 @default.
- W2022123095 cites W2013719051 @default.
- W2022123095 cites W2015772561 @default.
- W2022123095 cites W2016337007 @default.
- W2022123095 cites W2023666553 @default.
- W2022123095 cites W2028606580 @default.
- W2022123095 cites W2029227663 @default.
- W2022123095 cites W2040703859 @default.
- W2022123095 cites W2048529834 @default.
- W2022123095 cites W2051574299 @default.
- W2022123095 cites W2060645936 @default.
- W2022123095 cites W2066210317 @default.
- W2022123095 cites W2067193940 @default.
- W2022123095 cites W2068381394 @default.
- W2022123095 cites W2070147819 @default.
- W2022123095 cites W2074286790 @default.
- W2022123095 cites W2074776278 @default.
- W2022123095 cites W2082696563 @default.
- W2022123095 cites W2083547344 @default.
- W2022123095 cites W2089030274 @default.
- W2022123095 cites W2090806689 @default.
- W2022123095 cites W2093710529 @default.
- W2022123095 cites W2098553579 @default.
- W2022123095 cites W2100747076 @default.
- W2022123095 cites W2103924217 @default.
- W2022123095 cites W2104996004 @default.
- W2022123095 cites W2106628955 @default.
- W2022123095 cites W2139785595 @default.
- W2022123095 cites W2170809837 @default.
- W2022123095 cites W227580377 @default.
- W2022123095 cites W2276854697 @default.
- W2022123095 cites W2333540356 @default.
- W2022123095 cites W4231213647 @default.
- W2022123095 cites W4244611911 @default.
- W2022123095 cites W4246795590 @default.
- W2022123095 doi "https://doi.org/10.1111/j.1460-9568.1995.tb00334.x" @default.
- W2022123095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7773436" @default.
- W2022123095 hasPublicationYear "1995" @default.
- W2022123095 type Work @default.
- W2022123095 sameAs 2022123095 @default.
- W2022123095 citedByCount "182" @default.
- W2022123095 countsByYear W20221230952012 @default.
- W2022123095 countsByYear W20221230952013 @default.
- W2022123095 countsByYear W20221230952014 @default.
- W2022123095 countsByYear W20221230952015 @default.
- W2022123095 countsByYear W20221230952018 @default.
- W2022123095 countsByYear W20221230952019 @default.
- W2022123095 countsByYear W20221230952021 @default.
- W2022123095 countsByYear W20221230952022 @default.
- W2022123095 crossrefType "journal-article" @default.
- W2022123095 hasAuthorship W2022123095A5007980662 @default.
- W2022123095 hasAuthorship W2022123095A5013363726 @default.
- W2022123095 hasAuthorship W2022123095A5027802137 @default.
- W2022123095 hasAuthorship W2022123095A5034118095 @default.
- W2022123095 hasAuthorship W2022123095A5042898209 @default.
- W2022123095 hasAuthorship W2022123095A5043178995 @default.
- W2022123095 hasAuthorship W2022123095A5047805663 @default.
- W2022123095 hasAuthorship W2022123095A5089627681 @default.
- W2022123095 hasBestOaLocation W20221230952 @default.
- W2022123095 hasConcept C104317684 @default.
- W2022123095 hasConcept C121446783 @default.
- W2022123095 hasConcept C126322002 @default.
- W2022123095 hasConcept C134018914 @default.
- W2022123095 hasConcept C150194340 @default.
- W2022123095 hasConcept C2777099045 @default.