Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022124841> ?p ?o ?g. }
- W2022124841 abstract "During meiosis I (MI) in oocytes, the maturation-associated decrease of histone acetylation is critical for normal meiotic progression and accurate chromosome segregation. RBBP4 is a component of several different histone deacetylase containing chromatin-remodeling complexes, but RBBP4's role in regulating MI is not known. Depleting RBBP4 in mouse oocytes resulted in multipolar spindles at metaphase (Met) I with subsequent perturbed meiotic progression and increased incidence of abnormal spindles, chromosome misalignment, and aneuploidy at Met II. We attribute these defects to improper deacetylation of histones because histones H3K4, H4K8, H4K12, and H4K16 were hyperacetylated in RBBP4-depleted oocytes. Importantly, we show that RBBP4-mediated histone deacetylation is essential for regulating bipolar spindle assembly, at least partially, through promoting Aurora kinase (AURK) C function. To our knowledge, these results are the first to identify RBBP4 as a regulator of histone deacetylation during oocyte maturation, and they provide evidence that deacetylation is required for bipolar spindle assembly through AURKC." @default.
- W2022124841 created "2016-06-24" @default.
- W2022124841 creator A5002886426 @default.
- W2022124841 creator A5028438754 @default.
- W2022124841 creator A5061586848 @default.
- W2022124841 creator A5064003363 @default.
- W2022124841 date "2015-04-01" @default.
- W2022124841 modified "2023-09-25" @default.
- W2022124841 title "RBBP4 Regulates Histone Deacetylation and Bipolar Spindle Assembly During Oocyte Maturation in the Mouse1" @default.
- W2022124841 cites W1529934215 @default.
- W2022124841 cites W1974112332 @default.
- W2022124841 cites W1978570830 @default.
- W2022124841 cites W1990891770 @default.
- W2022124841 cites W1991234705 @default.
- W2022124841 cites W1997678453 @default.
- W2022124841 cites W2004658596 @default.
- W2022124841 cites W2007884336 @default.
- W2022124841 cites W2008952211 @default.
- W2022124841 cites W2014817033 @default.
- W2022124841 cites W2020714026 @default.
- W2022124841 cites W2021125311 @default.
- W2022124841 cites W2027370800 @default.
- W2022124841 cites W2037139350 @default.
- W2022124841 cites W2040483141 @default.
- W2022124841 cites W2041664737 @default.
- W2022124841 cites W2045496528 @default.
- W2022124841 cites W2046716387 @default.
- W2022124841 cites W2055597783 @default.
- W2022124841 cites W2061027592 @default.
- W2022124841 cites W2078826636 @default.
- W2022124841 cites W2079921190 @default.
- W2022124841 cites W2089806746 @default.
- W2022124841 cites W2090098801 @default.
- W2022124841 cites W2092819966 @default.
- W2022124841 cites W2113487949 @default.
- W2022124841 cites W2114265914 @default.
- W2022124841 cites W2128425744 @default.
- W2022124841 cites W2131278882 @default.
- W2022124841 cites W2132270941 @default.
- W2022124841 cites W2142514693 @default.
- W2022124841 cites W2144412383 @default.
- W2022124841 cites W2145155061 @default.
- W2022124841 cites W2148807789 @default.
- W2022124841 cites W2152480074 @default.
- W2022124841 cites W2155631307 @default.
- W2022124841 cites W2166516637 @default.
- W2022124841 cites W2168146428 @default.
- W2022124841 cites W2168359916 @default.
- W2022124841 cites W2171962628 @default.
- W2022124841 doi "https://doi.org/10.1095/biolreprod.115.128298" @default.
- W2022124841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4643954" @default.
- W2022124841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25788661" @default.
- W2022124841 hasPublicationYear "2015" @default.
- W2022124841 type Work @default.
- W2022124841 sameAs 2022124841 @default.
- W2022124841 citedByCount "28" @default.
- W2022124841 countsByYear W20221248412015 @default.
- W2022124841 countsByYear W20221248412016 @default.
- W2022124841 countsByYear W20221248412017 @default.
- W2022124841 countsByYear W20221248412018 @default.
- W2022124841 countsByYear W20221248412019 @default.
- W2022124841 countsByYear W20221248412020 @default.
- W2022124841 countsByYear W20221248412021 @default.
- W2022124841 countsByYear W20221248412022 @default.
- W2022124841 countsByYear W20221248412023 @default.
- W2022124841 crossrefType "journal-article" @default.
- W2022124841 hasAuthorship W2022124841A5002886426 @default.
- W2022124841 hasAuthorship W2022124841A5028438754 @default.
- W2022124841 hasAuthorship W2022124841A5061586848 @default.
- W2022124841 hasAuthorship W2022124841A5064003363 @default.
- W2022124841 hasBestOaLocation W20221248412 @default.
- W2022124841 hasConcept C104317684 @default.
- W2022124841 hasConcept C119157956 @default.
- W2022124841 hasConcept C148196450 @default.
- W2022124841 hasConcept C167227067 @default.
- W2022124841 hasConcept C196843134 @default.
- W2022124841 hasConcept C2776690073 @default.
- W2022124841 hasConcept C2778305200 @default.
- W2022124841 hasConcept C2778354886 @default.
- W2022124841 hasConcept C30481170 @default.
- W2022124841 hasConcept C54355233 @default.
- W2022124841 hasConcept C552990157 @default.
- W2022124841 hasConcept C64927066 @default.
- W2022124841 hasConcept C83640560 @default.
- W2022124841 hasConcept C86803240 @default.
- W2022124841 hasConcept C95444343 @default.
- W2022124841 hasConceptScore W2022124841C104317684 @default.
- W2022124841 hasConceptScore W2022124841C119157956 @default.
- W2022124841 hasConceptScore W2022124841C148196450 @default.
- W2022124841 hasConceptScore W2022124841C167227067 @default.
- W2022124841 hasConceptScore W2022124841C196843134 @default.
- W2022124841 hasConceptScore W2022124841C2776690073 @default.
- W2022124841 hasConceptScore W2022124841C2778305200 @default.
- W2022124841 hasConceptScore W2022124841C2778354886 @default.
- W2022124841 hasConceptScore W2022124841C30481170 @default.
- W2022124841 hasConceptScore W2022124841C54355233 @default.
- W2022124841 hasConceptScore W2022124841C552990157 @default.
- W2022124841 hasConceptScore W2022124841C64927066 @default.
- W2022124841 hasConceptScore W2022124841C83640560 @default.
- W2022124841 hasConceptScore W2022124841C86803240 @default.