Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022125881> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2022125881 endingPage "421" @default.
- W2022125881 startingPage "413" @default.
- W2022125881 abstract "Tobramycin dry powder formulations were evaluated by gamma scintigraphy and pharmacokinetic methods. In an open single-dose, three-treatment, three-period, cross-over study, nine cystic fibrosis patients received both the two test products and the reference product Tobi (nebulizer solution) in order to assess lung deposition and systemic comparative bioavailability of the two investigational inhaled products versus the marketed inhaled comparator product. The percentage of dose (mean+/-SD) in the whole lung was 53.0+/-10.0% for the tobramycin Form 1, 34.1+/-12.4% for the tobramycin Form 2 and 7.6+/-2.7% for the comparator product Tobi. Lung deposition expressed as a percentage of the nominal dose was thus estimated to be 7.0 and 4.5 times higher for the Tobra Form 1 and Tobra Form 2 than for the Tobi, respectively. Furthermore, the systemic bioavailability (adjusted to correspond to the same drug dose as that of the comparator product deposited in the lung) was found to be 1.6 times higher for the comparator product Tobi than for the two DPI formulations. The principal advantages of the DPI formulations include reduced systemic availability and thus, side effects, and higher dose levels of the drug at the site of drug action." @default.
- W2022125881 created "2016-06-24" @default.
- W2022125881 creator A5001772456 @default.
- W2022125881 creator A5016360559 @default.
- W2022125881 creator A5028921636 @default.
- W2022125881 creator A5037431401 @default.
- W2022125881 creator A5044389545 @default.
- W2022125881 creator A5046236293 @default.
- W2022125881 creator A5072750857 @default.
- W2022125881 date "2008-02-01" @default.
- W2022125881 modified "2023-10-10" @default.
- W2022125881 title "Pharmacoscintigraphic and pharmacokinetic evaluation of tobramycin DPI formulations in cystic fibrosis patients" @default.
- W2022125881 cites W1481098372 @default.
- W2022125881 cites W1986108334 @default.
- W2022125881 cites W1986413990 @default.
- W2022125881 cites W1986851079 @default.
- W2022125881 cites W2007183298 @default.
- W2022125881 cites W2009959447 @default.
- W2022125881 cites W2010566912 @default.
- W2022125881 cites W2033241761 @default.
- W2022125881 cites W2038217239 @default.
- W2022125881 cites W2051909136 @default.
- W2022125881 cites W2053597686 @default.
- W2022125881 cites W2055857822 @default.
- W2022125881 cites W2079185821 @default.
- W2022125881 cites W2090943591 @default.
- W2022125881 cites W2097553767 @default.
- W2022125881 cites W2101975583 @default.
- W2022125881 cites W2105443867 @default.
- W2022125881 cites W2116478659 @default.
- W2022125881 cites W2155069031 @default.
- W2022125881 cites W2160625057 @default.
- W2022125881 cites W2173528355 @default.
- W2022125881 doi "https://doi.org/10.1016/j.ejpb.2007.05.005" @default.
- W2022125881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17574400" @default.
- W2022125881 hasPublicationYear "2008" @default.
- W2022125881 type Work @default.
- W2022125881 sameAs 2022125881 @default.
- W2022125881 citedByCount "27" @default.
- W2022125881 countsByYear W20221258812012 @default.
- W2022125881 countsByYear W20221258812013 @default.
- W2022125881 countsByYear W20221258812014 @default.
- W2022125881 countsByYear W20221258812016 @default.
- W2022125881 countsByYear W20221258812018 @default.
- W2022125881 countsByYear W20221258812019 @default.
- W2022125881 countsByYear W20221258812020 @default.
- W2022125881 countsByYear W20221258812021 @default.
- W2022125881 crossrefType "journal-article" @default.
- W2022125881 hasAuthorship W2022125881A5001772456 @default.
- W2022125881 hasAuthorship W2022125881A5016360559 @default.
- W2022125881 hasAuthorship W2022125881A5028921636 @default.
- W2022125881 hasAuthorship W2022125881A5037431401 @default.
- W2022125881 hasAuthorship W2022125881A5044389545 @default.
- W2022125881 hasAuthorship W2022125881A5046236293 @default.
- W2022125881 hasAuthorship W2022125881A5072750857 @default.
- W2022125881 hasConcept C112705442 @default.
- W2022125881 hasConcept C181389837 @default.
- W2022125881 hasConcept C185592680 @default.
- W2022125881 hasConcept C2775832221 @default.
- W2022125881 hasConcept C2778974779 @default.
- W2022125881 hasConcept C2780035454 @default.
- W2022125881 hasConcept C501593827 @default.
- W2022125881 hasConcept C55493867 @default.
- W2022125881 hasConcept C71924100 @default.
- W2022125881 hasConcept C98274493 @default.
- W2022125881 hasConceptScore W2022125881C112705442 @default.
- W2022125881 hasConceptScore W2022125881C181389837 @default.
- W2022125881 hasConceptScore W2022125881C185592680 @default.
- W2022125881 hasConceptScore W2022125881C2775832221 @default.
- W2022125881 hasConceptScore W2022125881C2778974779 @default.
- W2022125881 hasConceptScore W2022125881C2780035454 @default.
- W2022125881 hasConceptScore W2022125881C501593827 @default.
- W2022125881 hasConceptScore W2022125881C55493867 @default.
- W2022125881 hasConceptScore W2022125881C71924100 @default.
- W2022125881 hasConceptScore W2022125881C98274493 @default.
- W2022125881 hasIssue "2" @default.
- W2022125881 hasLocation W20221258811 @default.
- W2022125881 hasLocation W20221258812 @default.
- W2022125881 hasOpenAccess W2022125881 @default.
- W2022125881 hasPrimaryLocation W20221258811 @default.
- W2022125881 hasRelatedWork W16113689 @default.
- W2022125881 hasRelatedWork W2045537220 @default.
- W2022125881 hasRelatedWork W2141289501 @default.
- W2022125881 hasRelatedWork W2162491061 @default.
- W2022125881 hasRelatedWork W2370616901 @default.
- W2022125881 hasRelatedWork W2960553615 @default.
- W2022125881 hasRelatedWork W3043458966 @default.
- W2022125881 hasRelatedWork W3095294855 @default.
- W2022125881 hasRelatedWork W4364376666 @default.
- W2022125881 hasRelatedWork W2185800696 @default.
- W2022125881 hasVolume "68" @default.
- W2022125881 isParatext "false" @default.
- W2022125881 isRetracted "false" @default.
- W2022125881 magId "2022125881" @default.
- W2022125881 workType "article" @default.