FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022126020> ?p ?o ?g. }

• W2022126020 endingPage "600" @default.
• W2022126020 startingPage "593" @default.
• W2022126020 abstract "Our previous work demonstrated dexmedetomidine-activated phosphorylation of extracellular regulated kinases 1 and 2 (ERK1/2) in primary cultures of mouse astrocytes and showed that it is evoked by α2-adrenoceptor-mediated transactivation of epidermal growth factor (EGF) receptors, a known response to activation of Gi/o- or Gq-coupled receptors [Li, B., Du, T., Li, H., Gu, L., Zhang, H., Huang, J., Hertz, L., Peng, L., 2008a. Signaling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons. Br. J. Pharmacol. 154, 191–203]. Like most studies of transactivation, that study used cultured cells, raising the question whether a similar effect can be demonstrated in intact brain tissue and the brain in vivo. In the present study we have shown that (i) dexmedetomidine-mediated ERK1/2 phosphorylation occurs in mouse brain slices with a similar concentration dependence as in cultured astrocytes (near-maximum effect at 50 nM); (ii) intraperitoneal injection of dexmedetomidine (3 μg/kg) in adult mice causes rapid phosphorylation of the EGF receptor (at Y845 and Y992) and of ERK1/2 in the brain; (iii) both EGF receptor and ERK1/2 phosphorylation are inhibited by intraventricular administration of (a) AG 1478, a specific inhibitor of the receptor-tyrosine kinase of the EGF receptor; (b) GM 6001, an inhibitor of metalloproteinase(s) required for release of EGF receptor agonists from membrane-bound precursors; or (c) heparin, neutralizing heparin-binding EGF (HB-EGF). Thus, in intact brain HB-EGF, known to be expressed in brain, may be the major EGF agonist released in response to stimulation of α2-adrenoceptors, the released agonist(s) activate(s) EGF receptors, and ERK1/2 is phosphorylated as a conventional response to EGF receptor activation. Our previous paper (see above) showed that dexmedetomidine evokes no ERK1/2 phosphorylation in cultured neurons, but neurons respond to astrocyte-conditioned medium (and to EGF) with ERK1/2 phosphorylation. The present findings therefore suggest that EGF receptor transactivation in astrocytes in the mature brain in vivo is an important process in response to α2-adrenoceptor stimulation and may lead to phosphorylation of ERK1/2 both in astrocytes themselves and in adjacent neurons." @default.
• W2022126020 created "2016-06-24" @default.
• W2022126020 creator A5006219225 @default.
• W2022126020 creator A5022130217 @default.
• W2022126020 creator A5030602169 @default.
• W2022126020 creator A5051915554 @default.
• W2022126020 creator A5061796601 @default.
• W2022126020 creator A5066975218 @default.
• W2022126020 creator A5083058332 @default.
• W2022126020 date "2009-12-01" @default.
• W2022126020 modified "2023-09-25" @default.
• W2022126020 title "ERK phosphorylation in intact, adult brain by α2-adrenergic transactivation of EGF receptors" @default.
• W2022126020 cites W1529444545 @default.
• W2022126020 cites W1550554578 @default.
• W2022126020 cites W1593708032 @default.
• W2022126020 cites W1779147517 @default.
• W2022126020 cites W1820089171 @default.
• W2022126020 cites W1968625794 @default.
• W2022126020 cites W1969568346 @default.
• W2022126020 cites W1970116189 @default.
• W2022126020 cites W1973613551 @default.
• W2022126020 cites W1973728200 @default.
• W2022126020 cites W1978666210 @default.
• W2022126020 cites W1981336142 @default.
• W2022126020 cites W1982835803 @default.
• W2022126020 cites W1992271847 @default.
• W2022126020 cites W1997541998 @default.
• W2022126020 cites W1998041648 @default.
• W2022126020 cites W1999485470 @default.
• W2022126020 cites W2000018178 @default.
• W2022126020 cites W2005337889 @default.
• W2022126020 cites W2017573472 @default.
• W2022126020 cites W2020657920 @default.
• W2022126020 cites W2022526869 @default.
• W2022126020 cites W2022908550 @default.
• W2022126020 cites W2025829561 @default.
• W2022126020 cites W2027177846 @default.
• W2022126020 cites W2027898789 @default.
• W2022126020 cites W2030698030 @default.
• W2022126020 cites W2033479223 @default.
• W2022126020 cites W2036228531 @default.
• W2022126020 cites W2038159281 @default.
• W2022126020 cites W2041025793 @default.
• W2022126020 cites W2042642856 @default.
• W2022126020 cites W2043739859 @default.
• W2022126020 cites W2044455815 @default.
• W2022126020 cites W2044891859 @default.
• W2022126020 cites W2054436296 @default.
• W2022126020 cites W2055883939 @default.
• W2022126020 cites W2058450217 @default.
• W2022126020 cites W2058839845 @default.
• W2022126020 cites W2063077682 @default.
• W2022126020 cites W2072219853 @default.
• W2022126020 cites W2072467054 @default.
• W2022126020 cites W2075528368 @default.
• W2022126020 cites W2080060830 @default.
• W2022126020 cites W2080961341 @default.
• W2022126020 cites W2081755725 @default.
• W2022126020 cites W2082002150 @default.
• W2022126020 cites W2092619681 @default.
• W2022126020 cites W2106711747 @default.
• W2022126020 cites W2120144854 @default.
• W2022126020 cites W2132842237 @default.
• W2022126020 cites W2133662417 @default.
• W2022126020 cites W2147246461 @default.
• W2022126020 cites W2155989580 @default.
• W2022126020 cites W2168530623 @default.
• W2022126020 cites W2169341893 @default.
• W2022126020 cites W4211245842 @default.
• W2022126020 cites W4240143568 @default.
• W2022126020 cites W4293247451 @default.
• W2022126020 doi "https://doi.org/10.1016/j.neuint.2009.05.016" @default.
• W2022126020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19501623" @default.
• W2022126020 hasPublicationYear "2009" @default.
• W2022126020 type Work @default.
• W2022126020 sameAs 2022126020 @default.
• W2022126020 citedByCount "32" @default.
• W2022126020 countsByYear W20221260202013 @default.
• W2022126020 countsByYear W20221260202014 @default.
• W2022126020 countsByYear W20221260202015 @default.
• W2022126020 countsByYear W20221260202016 @default.
• W2022126020 countsByYear W20221260202018 @default.
• W2022126020 countsByYear W20221260202019 @default.
• W2022126020 countsByYear W20221260202020 @default.
• W2022126020 countsByYear W20221260202021 @default.
• W2022126020 countsByYear W20221260202023 @default.
• W2022126020 crossrefType "journal-article" @default.
• W2022126020 hasAuthorship W2022126020A5006219225 @default.
• W2022126020 hasAuthorship W2022126020A5022130217 @default.
• W2022126020 hasAuthorship W2022126020A5030602169 @default.
• W2022126020 hasAuthorship W2022126020A5051915554 @default.
• W2022126020 hasAuthorship W2022126020A5061796601 @default.
• W2022126020 hasAuthorship W2022126020A5066975218 @default.
• W2022126020 hasAuthorship W2022126020A5083058332 @default.
• W2022126020 hasConcept C104317684 @default.
• W2022126020 hasConcept C11960822 @default.
• W2022126020 hasConcept C126322002 @default.
• W2022126020 hasConcept C1292079 @default.

• next