Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022126078> ?p ?o ?g. }
- W2022126078 endingPage "253" @default.
- W2022126078 startingPage "248" @default.
- W2022126078 abstract "Purpose of review An increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consequences of this observation. Recent findings Autoantigens from dying cells trigger plasmacytoid dendritic cells to a continuous synthesis of type I IFN, which is promoted by natural killer (NK) cells and B cells. A growing number of genes connected to type I IFN production and response associates with an increased susceptibility to autoimmunity. Besides type I IFN, type III IFN (IFN-λ) may contribute to the IFN signature. In SLE and primary Sjögren's syndrome, a prominent IFN signature is connected to an active disease, whereas in rheumatoid arthritis the IFN signature defines a disease subset with poor clinical outcome and treatment failure to B-cell depleting therapy. Several therapies aiming to inhibit the IFN signature are in clinical trials and early data suggest clinical benefits without major safety problems. Summary The observed IFN signature in several autoimmune diseases is a biomarker of active disease and is investigated as a tool when selecting treatment for individual patients." @default.
- W2022126078 created "2016-06-24" @default.
- W2022126078 creator A5055854855 @default.
- W2022126078 creator A5078557164 @default.
- W2022126078 date "2013-03-01" @default.
- W2022126078 modified "2023-10-15" @default.
- W2022126078 title "The interferon signature in autoimmune diseases" @default.
- W2022126078 cites W1531708107 @default.
- W2022126078 cites W156829367 @default.
- W2022126078 cites W1848507162 @default.
- W2022126078 cites W1852489937 @default.
- W2022126078 cites W1967844530 @default.
- W2022126078 cites W1974652539 @default.
- W2022126078 cites W1988240374 @default.
- W2022126078 cites W1999218213 @default.
- W2022126078 cites W2006353424 @default.
- W2022126078 cites W2018078765 @default.
- W2022126078 cites W2028312550 @default.
- W2022126078 cites W2028689735 @default.
- W2022126078 cites W2033194420 @default.
- W2022126078 cites W2040733258 @default.
- W2022126078 cites W2044085031 @default.
- W2022126078 cites W2057801606 @default.
- W2022126078 cites W2058484339 @default.
- W2022126078 cites W2062713016 @default.
- W2022126078 cites W2070359556 @default.
- W2022126078 cites W2071978180 @default.
- W2022126078 cites W2075283457 @default.
- W2022126078 cites W2075715794 @default.
- W2022126078 cites W2080549619 @default.
- W2022126078 cites W2084676421 @default.
- W2022126078 cites W2084951281 @default.
- W2022126078 cites W2091018161 @default.
- W2022126078 cites W2092606926 @default.
- W2022126078 cites W2093547968 @default.
- W2022126078 cites W2094670790 @default.
- W2022126078 cites W2100382163 @default.
- W2022126078 cites W2104590104 @default.
- W2022126078 cites W2106273198 @default.
- W2022126078 cites W2117159031 @default.
- W2022126078 cites W2117433422 @default.
- W2022126078 cites W2121592594 @default.
- W2022126078 cites W2122295644 @default.
- W2022126078 cites W2122995291 @default.
- W2022126078 cites W2127198764 @default.
- W2022126078 cites W2136590838 @default.
- W2022126078 cites W2141314333 @default.
- W2022126078 cites W2149380153 @default.
- W2022126078 cites W2151463001 @default.
- W2022126078 cites W2154243191 @default.
- W2022126078 cites W2167314990 @default.
- W2022126078 cites W2167736693 @default.
- W2022126078 cites W2168197335 @default.
- W2022126078 cites W2168888135 @default.
- W2022126078 cites W2316480313 @default.
- W2022126078 doi "https://doi.org/10.1097/bor.0b013e32835c7e32" @default.
- W2022126078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23249830" @default.
- W2022126078 hasPublicationYear "2013" @default.
- W2022126078 type Work @default.
- W2022126078 sameAs 2022126078 @default.
- W2022126078 citedByCount "241" @default.
- W2022126078 countsByYear W20221260782013 @default.
- W2022126078 countsByYear W20221260782014 @default.
- W2022126078 countsByYear W20221260782015 @default.
- W2022126078 countsByYear W20221260782016 @default.
- W2022126078 countsByYear W20221260782017 @default.
- W2022126078 countsByYear W20221260782018 @default.
- W2022126078 countsByYear W20221260782019 @default.
- W2022126078 countsByYear W20221260782020 @default.
- W2022126078 countsByYear W20221260782021 @default.
- W2022126078 countsByYear W20221260782022 @default.
- W2022126078 countsByYear W20221260782023 @default.
- W2022126078 crossrefType "journal-article" @default.
- W2022126078 hasAuthorship W2022126078A5055854855 @default.
- W2022126078 hasAuthorship W2022126078A5078557164 @default.
- W2022126078 hasConcept C104317684 @default.
- W2022126078 hasConcept C126322002 @default.
- W2022126078 hasConcept C150194340 @default.
- W2022126078 hasConcept C159654299 @default.
- W2022126078 hasConcept C203014093 @default.
- W2022126078 hasConcept C2776178377 @default.
- W2022126078 hasConcept C2777575956 @default.
- W2022126078 hasConcept C2778278966 @default.
- W2022126078 hasConcept C2779075594 @default.
- W2022126078 hasConcept C2779134260 @default.
- W2022126078 hasConcept C2779733811 @default.
- W2022126078 hasConcept C2780130043 @default.
- W2022126078 hasConcept C2781197716 @default.
- W2022126078 hasConcept C54355233 @default.
- W2022126078 hasConcept C71924100 @default.
- W2022126078 hasConcept C86803240 @default.
- W2022126078 hasConceptScore W2022126078C104317684 @default.
- W2022126078 hasConceptScore W2022126078C126322002 @default.
- W2022126078 hasConceptScore W2022126078C150194340 @default.
- W2022126078 hasConceptScore W2022126078C159654299 @default.
- W2022126078 hasConceptScore W2022126078C203014093 @default.
- W2022126078 hasConceptScore W2022126078C2776178377 @default.
- W2022126078 hasConceptScore W2022126078C2777575956 @default.