Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022126917> ?p ?o ?g. }
- W2022126917 endingPage "2019" @default.
- W2022126917 startingPage "2015" @default.
- W2022126917 abstract "Abstract Red blood cells deliver O2 from the lungs to every cell in the human body. Reduced tissue oxygenation triggers increased production of erythropoietin by hypoxia-inducible factor 1 (HIF-1), which is a transcriptional activator composed of an O2-regulated α subunit and a constitutively expressed β subunit. Hydroxylation of HIF-1α or HIF-2α by the asparaginyl hydroxylase FIH-1 blocks coactivator binding and transactivation. Hydroxylation of HIF-1α or HIF-2α by the prolyl hydroxylase PHD2 is required for binding of the von Hippel-Lindau protein (VHL), leading to ubiquitination and proteasomal degradation. Mutations in the genes encoding VHL, PHD2, and HIF-2α have been identified in patients with familial erythrocytosis. Patients with Chuvash polycythemia, who are homozygous for a missense mutation in the VHL gene, have multisystem pathology attributable to dysregulated oxygen homeostasis. Intense efforts are under way to identify small molecule hydroxylase inhibitors that can be administered chronically to selectively induce erythropoiesis without undesirable side effects." @default.
- W2022126917 created "2016-06-24" @default.
- W2022126917 creator A5051276665 @default.
- W2022126917 date "2009-09-03" @default.
- W2022126917 modified "2023-09-30" @default.
- W2022126917 title "Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis" @default.
- W2022126917 cites W132238687 @default.
- W2022126917 cites W1521696202 @default.
- W2022126917 cites W1536433213 @default.
- W2022126917 cites W1749022239 @default.
- W2022126917 cites W1937401270 @default.
- W2022126917 cites W1967194906 @default.
- W2022126917 cites W1967855521 @default.
- W2022126917 cites W1970290216 @default.
- W2022126917 cites W1972590090 @default.
- W2022126917 cites W1975984062 @default.
- W2022126917 cites W1981487137 @default.
- W2022126917 cites W1984604224 @default.
- W2022126917 cites W1991047577 @default.
- W2022126917 cites W1991843895 @default.
- W2022126917 cites W1997422780 @default.
- W2022126917 cites W2000457934 @default.
- W2022126917 cites W2005868568 @default.
- W2022126917 cites W2007919022 @default.
- W2022126917 cites W2008430621 @default.
- W2022126917 cites W2011562442 @default.
- W2022126917 cites W2017575850 @default.
- W2022126917 cites W2020277250 @default.
- W2022126917 cites W2024206845 @default.
- W2022126917 cites W2024229944 @default.
- W2022126917 cites W2028331311 @default.
- W2022126917 cites W2030334534 @default.
- W2022126917 cites W2040031153 @default.
- W2022126917 cites W2042216712 @default.
- W2022126917 cites W2044257922 @default.
- W2022126917 cites W2046628354 @default.
- W2022126917 cites W2052553321 @default.
- W2022126917 cites W2056714071 @default.
- W2022126917 cites W2059951197 @default.
- W2022126917 cites W2070261550 @default.
- W2022126917 cites W2080727542 @default.
- W2022126917 cites W2085609942 @default.
- W2022126917 cites W2086913408 @default.
- W2022126917 cites W2089692551 @default.
- W2022126917 cites W2090627731 @default.
- W2022126917 cites W2095582000 @default.
- W2022126917 cites W2098972920 @default.
- W2022126917 cites W2099667514 @default.
- W2022126917 cites W2102476325 @default.
- W2022126917 cites W2108582916 @default.
- W2022126917 cites W2109492293 @default.
- W2022126917 cites W2114742129 @default.
- W2022126917 cites W2116374020 @default.
- W2022126917 cites W2129932871 @default.
- W2022126917 cites W2135034560 @default.
- W2022126917 cites W2135836641 @default.
- W2022126917 cites W2136875815 @default.
- W2022126917 cites W2144625075 @default.
- W2022126917 cites W2149736876 @default.
- W2022126917 cites W2153376781 @default.
- W2022126917 cites W2153771223 @default.
- W2022126917 cites W2156639415 @default.
- W2022126917 cites W2170559724 @default.
- W2022126917 doi "https://doi.org/10.1182/blood-2009-05-189985" @default.
- W2022126917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19494350" @default.
- W2022126917 hasPublicationYear "2009" @default.
- W2022126917 type Work @default.
- W2022126917 sameAs 2022126917 @default.
- W2022126917 citedByCount "197" @default.
- W2022126917 countsByYear W20221269172012 @default.
- W2022126917 countsByYear W20221269172013 @default.
- W2022126917 countsByYear W20221269172014 @default.
- W2022126917 countsByYear W20221269172015 @default.
- W2022126917 countsByYear W20221269172016 @default.
- W2022126917 countsByYear W20221269172017 @default.
- W2022126917 countsByYear W20221269172018 @default.
- W2022126917 countsByYear W20221269172019 @default.
- W2022126917 countsByYear W20221269172020 @default.
- W2022126917 countsByYear W20221269172021 @default.
- W2022126917 countsByYear W20221269172022 @default.
- W2022126917 countsByYear W20221269172023 @default.
- W2022126917 crossrefType "journal-article" @default.
- W2022126917 hasAuthorship W2022126917A5051276665 @default.
- W2022126917 hasBestOaLocation W20221269171 @default.
- W2022126917 hasConcept C104292427 @default.
- W2022126917 hasConcept C104317684 @default.
- W2022126917 hasConcept C126322002 @default.
- W2022126917 hasConcept C1292079 @default.
- W2022126917 hasConcept C134018914 @default.
- W2022126917 hasConcept C153911025 @default.
- W2022126917 hasConcept C160450060 @default.
- W2022126917 hasConcept C181199279 @default.
- W2022126917 hasConcept C27740335 @default.
- W2022126917 hasConcept C2778248108 @default.
- W2022126917 hasConcept C2778534260 @default.
- W2022126917 hasConcept C2779703530 @default.
- W2022126917 hasConcept C2781109383 @default.
- W2022126917 hasConcept C501734568 @default.