FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022127741> ?p ?o ?g. }

• W2022127741 endingPage "607" @default.
• W2022127741 startingPage "595" @default.
• W2022127741 abstract "Alopecia is defined as hair loss in a part of the head due to various causes, such as drugs, stress and autoimmune disorders. Various therapeutic agents have been suggested depending on the cause of the condition and patient sex, and age. Minoxidil (MXD) is commonly used topically to treat alopecia, but its low absorption rate limits widespread use. To overcome the low absorption, we suggest microneedles (MNs) as controlled drug delivery systems that release MXD. We used hyaluronic acid (HA) to construct MN, as it is biocompatible and safe. We examined the effect of HA on the hair dermal papilla (HDP) cells that control the development of hair follicles. HA enhanced proliferation, migration, and aggregation of HDP cell by increasing cell-cell adhesion and decreasing cell substratum. These effects were mediated by the cluster of differentiation (CD)-44 and phosphorylation of serine‑threonine kinase (Akt). In chemotherapy-induced alopecia mice, topical application of HA tended to decrease chemotherapy-induced hair loss. Although the amount of MXD administered by HA-MNs was 10% of topical treatment, the MXD-containing HA-MNs (MXD-HA-MNs) showed better effects on the growth of hair than topical application of MXD. In summary, our results demonstrated that HA reduces hair loss in alopecia mice, and that delivery of MXD and HA using MXD-HA-MNs maximizes therapeutic effects and minimize the side effects of MXD for the treatment of alopecia.(1) Significance, This work reports a new approach for treatment of alopecia using a dissolving microneedle (MN) prepared with hyaluronic acid (HA). The HA provided a better environment for cellular functions in the hair dermal papilla cells. The HA-MNs containing minoxidil (MXD) exhibited a significant reduction of hair loss, although amount of MXD contained in them was only 10% of topically applied MXD., (2) Scientific impact, This is the first report demonstrating the direct anti-alopecia effects of HA administrated in a transdermal route and the feasibility of novel therapeutics using MXD-containing HA-MNs. We believe that our work will excite interdisciplinary readers of Acta Biomaterialia, those who are interested in the natural polymers, drug delivery, and alopecia." @default.
• W2022127741 created "2016-06-24" @default.
• W2022127741 creator A5002660081 @default.
• W2022127741 creator A5056364096 @default.
• W2022127741 creator A5075932313 @default.
• W2022127741 date "1996-10-01" @default.
• W2022127741 modified "2023-10-09" @default.
• W2022127741 title "WHOLE HAIR FOLLICLE CULTURE" @default.
• W2022127741 cites W1501449846 @default.
• W2022127741 cites W1546741967 @default.
• W2022127741 cites W1571669934 @default.
• W2022127741 cites W1927300791 @default.
• W2022127741 cites W1968403409 @default.
• W2022127741 cites W1969865686 @default.
• W2022127741 cites W1970672045 @default.
• W2022127741 cites W1972922548 @default.
• W2022127741 cites W1974528641 @default.
• W2022127741 cites W1976351613 @default.
• W2022127741 cites W1976917706 @default.
• W2022127741 cites W1982577025 @default.
• W2022127741 cites W1983337434 @default.
• W2022127741 cites W1983816227 @default.
• W2022127741 cites W1984497928 @default.
• W2022127741 cites W1987939697 @default.
• W2022127741 cites W1990099810 @default.
• W2022127741 cites W1990826821 @default.
• W2022127741 cites W1994951597 @default.
• W2022127741 cites W1995407415 @default.
• W2022127741 cites W2007110811 @default.
• W2022127741 cites W2013943946 @default.
• W2022127741 cites W2021025871 @default.
• W2022127741 cites W2021843918 @default.
• W2022127741 cites W2034814488 @default.
• W2022127741 cites W2036634430 @default.
• W2022127741 cites W2046608680 @default.
• W2022127741 cites W2047823424 @default.
• W2022127741 cites W2051349486 @default.
• W2022127741 cites W2052839235 @default.
• W2022127741 cites W2053501481 @default.
• W2022127741 cites W2055907765 @default.
• W2022127741 cites W2059542071 @default.
• W2022127741 cites W2062763609 @default.
• W2022127741 cites W2067298482 @default.
• W2022127741 cites W2067388223 @default.
• W2022127741 cites W2072857243 @default.
• W2022127741 cites W2074989672 @default.
• W2022127741 cites W2075573504 @default.
• W2022127741 cites W2084368791 @default.
• W2022127741 cites W2089714332 @default.
• W2022127741 cites W2093710137 @default.
• W2022127741 cites W2140327883 @default.
• W2022127741 cites W2284084499 @default.
• W2022127741 cites W2323734143 @default.
• W2022127741 cites W2334797450 @default.
• W2022127741 cites W2343997548 @default.
• W2022127741 cites W2405611952 @default.
• W2022127741 cites W2411257287 @default.
• W2022127741 cites W2462127728 @default.
• W2022127741 cites W2492711107 @default.
• W2022127741 cites W2885860057 @default.
• W2022127741 cites W3163021115 @default.
• W2022127741 cites W4298313271 @default.
• W2022127741 doi "https://doi.org/10.1016/s0733-8635(05)70387-9" @default.
• W2022127741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9238319" @default.
• W2022127741 hasPublicationYear "1996" @default.
• W2022127741 type Work @default.
• W2022127741 sameAs 2022127741 @default.
• W2022127741 citedByCount "56" @default.
• W2022127741 countsByYear W20221277412013 @default.
• W2022127741 countsByYear W20221277412014 @default.
• W2022127741 countsByYear W20221277412015 @default.
• W2022127741 countsByYear W20221277412016 @default.
• W2022127741 countsByYear W20221277412017 @default.
• W2022127741 countsByYear W20221277412018 @default.
• W2022127741 countsByYear W20221277412019 @default.
• W2022127741 countsByYear W20221277412020 @default.
• W2022127741 countsByYear W20221277412021 @default.
• W2022127741 countsByYear W20221277412022 @default.
• W2022127741 countsByYear W20221277412023 @default.
• W2022127741 crossrefType "journal-article" @default.
• W2022127741 hasAuthorship W2022127741A5002660081 @default.
• W2022127741 hasAuthorship W2022127741A5056364096 @default.
• W2022127741 hasAuthorship W2022127741A5075932313 @default.
• W2022127741 hasConcept C105702510 @default.
• W2022127741 hasConcept C126322002 @default.
• W2022127741 hasConcept C134018914 @default.
• W2022127741 hasConcept C16005928 @default.
• W2022127741 hasConcept C185592680 @default.
• W2022127741 hasConcept C2776360568 @default.
• W2022127741 hasConcept C2776694085 @default.
• W2022127741 hasConcept C2777216303 @default.
• W2022127741 hasConcept C2777524370 @default.
• W2022127741 hasConcept C2777529286 @default.
• W2022127741 hasConcept C2779711729 @default.
• W2022127741 hasConcept C71924100 @default.
• W2022127741 hasConcept C98274493 @default.
• W2022127741 hasConceptScore W2022127741C105702510 @default.
• W2022127741 hasConceptScore W2022127741C126322002 @default.

• next