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- W2022127942 endingPage "e27714" @default.
- W2022127942 startingPage "e27714" @default.
- W2022127942 abstract "The host immune response contributes to the onset and progression of severe malaria syndromes, such as cerebral malaria. Adjunctive immunomodulatory strategies for severe malaria may improve clinical outcome beyond that achievable with artemisinin-based therapy alone. Here, we report that prophylaxis with inhaled nitric oxide significantly reduced systemic inflammation (lower TNF, IFNγ and MCP-1 in peripheral blood) and endothelial activation (decreased sICAM-1 and vWF, and increased angiopoeitin-1 levels in peripheral blood) in an experimental cerebral malaria model. Mice that received inhaled nitric oxide starting prior to infection had reduced parasitized erythrocyte accumulation in the brain, decreased brain expression of ICAM-1, and preserved vascular integrity compared to control mice. Inhaled nitric oxide administered in combination with artesunate, starting as late as 5.5 days post-infection, improved survival over treatment with artesunate alone (70% survival in the artesunate only vs. 100% survival in the artesunate plus iNO group, p = 0.03). These data support the clinical investigation of inhaled nitric oxide as a novel adjunctive therapy in patients with severe malaria." @default.
- W2022127942 created "2016-06-24" @default.
- W2022127942 creator A5015314211 @default.
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- W2022127942 creator A5061090632 @default.
- W2022127942 creator A5073059702 @default.
- W2022127942 creator A5074700955 @default.
- W2022127942 date "2011-11-16" @default.
- W2022127942 modified "2023-10-16" @default.
- W2022127942 title "Inhaled Nitric Oxide Reduces Endothelial Activation and Parasite Accumulation in the Brain, and Enhances Survival in Experimental Cerebral Malaria" @default.
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