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• W2022128299 endingPage "78" @default.
• W2022128299 startingPage "58" @default.
• W2022128299 abstract "HDAC inhibitors (HDACI) are now emerging as one of the most promising new classes of drugs for the treatment of select forms of non-Hodgkin's lymphoma (NHL). They are particularly active in T-cell lymphomas, possibly hodgkin's lymphoma and indolent B cell lymphomas. Presently, two of these agents, vorinostat and romidepsin, have been approved in the US for the treatment of relapsed and refractory cutaneous T cell lymphomas (CTCL). Initially, these agents were developed with the idea that they affected transcriptional activation and thus gene expression, by modulating chromatin condensation and decondensation. It is now clear that their effects go beyond chromatin and by affecting the acetylation status of histones and other intra-cellular proteins, they modify gene expression and cellular function via multiple pathways. Gene expression profiles and functional genetic analysis has led to further understanding of the various molecular pathways that are affected by these agents including cell cycle regulation, pathways of cellular proliferation, apoptosis and angiogenesis all important in lymphomagenesis. There is also increasing data to support the effects of these agents on T cell receptor and immune function which may explain the high level of activity of these agents in T cell lymphomas and hodgkin's lymphoma. There is ample evidence of epigenetic dysregulation in lymphomas which may underlie the mechanisms of action of these agents but how these agents work is still not clear. Current HDAC inhibitors can be divided into at least four classes based on their chemical structure. At present several of these HDAC inhibitors are in clinical trials both as single agents and in combination with chemotherapy or other biological agents. They are easy to administer and are generally well tolerated with minimal side effects. Different dosing levels and schedules and the use of isospecific HDAC inhibitors are some of the strategies that are being employed to increase the therapeutic effect of these agents in the treatment of lymphomas. There may also be class differences that translate into specific activity against different lymphoma. HDAC inhibitors will likely be incorporated into combinations of targeted therapies both in the upfront and relapsed setting for lymphomas." @default.
• W2022128299 created "2016-06-24" @default.
• W2022128299 creator A5002126535 @default.
• W2022128299 creator A5013307217 @default.
• W2022128299 date "2010-12-01" @default.
• W2022128299 modified "2023-10-06" @default.
• W2022128299 title "Targeting histone deacetyalses in the treatment of B- and T-cell malignancies" @default.
• W2022128299 cites W1522139704 @default.
• W2022128299 cites W154212680 @default.
• W2022128299 cites W1567485746 @default.
• W2022128299 cites W1587947784 @default.
• W2022128299 cites W160911776 @default.
• W2022128299 cites W1634638391 @default.
• W2022128299 cites W1791183093 @default.
• W2022128299 cites W1910848366 @default.
• W2022128299 cites W1965008416 @default.
• W2022128299 cites W1965262464 @default.
• W2022128299 cites W1965837349 @default.
• W2022128299 cites W1968356004 @default.
• W2022128299 cites W1968758858 @default.
• W2022128299 cites W1968972540 @default.
• W2022128299 cites W1972168709 @default.
• W2022128299 cites W1974090542 @default.
• W2022128299 cites W1977911898 @default.
• W2022128299 cites W1978664410 @default.
• W2022128299 cites W1985845937 @default.
• W2022128299 cites W1986250542 @default.
• W2022128299 cites W1986938005 @default.
• W2022128299 cites W1990011854 @default.
• W2022128299 cites W1994198833 @default.
• W2022128299 cites W1995522763 @default.
• W2022128299 cites W1997309716 @default.
• W2022128299 cites W1999080103 @default.
• W2022128299 cites W2003600960 @default.
• W2022128299 cites W2004800182 @default.
• W2022128299 cites W2006978594 @default.
• W2022128299 cites W2007268478 @default.
• W2022128299 cites W2012753961 @default.
• W2022128299 cites W2014732130 @default.
• W2022128299 cites W2016704490 @default.
• W2022128299 cites W2017340736 @default.
• W2022128299 cites W2024425375 @default.
• W2022128299 cites W2024527294 @default.
• W2022128299 cites W2031046263 @default.
• W2022128299 cites W2032486213 @default.
• W2022128299 cites W2041466047 @default.
• W2022128299 cites W2042322422 @default.
• W2022128299 cites W2043103226 @default.
• W2022128299 cites W2044578262 @default.
• W2022128299 cites W2047542386 @default.
• W2022128299 cites W2049569276 @default.
• W2022128299 cites W2051503798 @default.
• W2022128299 cites W2052181006 @default.
• W2022128299 cites W2054307692 @default.
• W2022128299 cites W2054848045 @default.
• W2022128299 cites W2058232002 @default.
• W2022128299 cites W2059238397 @default.
• W2022128299 cites W2061497413 @default.
• W2022128299 cites W2065882807 @default.
• W2022128299 cites W2067510388 @default.
• W2022128299 cites W2069019880 @default.
• W2022128299 cites W2071115015 @default.
• W2022128299 cites W2072669480 @default.
• W2022128299 cites W2079003739 @default.
• W2022128299 cites W2079054460 @default.
• W2022128299 cites W2086172979 @default.
• W2022128299 cites W2087877138 @default.
• W2022128299 cites W2092722802 @default.
• W2022128299 cites W2093070825 @default.
• W2022128299 cites W2094623849 @default.
• W2022128299 cites W2096160655 @default.
• W2022128299 cites W2098536205 @default.
• W2022128299 cites W2100589019 @default.
• W2022128299 cites W2100972878 @default.
• W2022128299 cites W2102169774 @default.
• W2022128299 cites W2102650381 @default.
• W2022128299 cites W2103789449 @default.
• W2022128299 cites W2104535331 @default.
• W2022128299 cites W2107040737 @default.
• W2022128299 cites W2108574775 @default.
• W2022128299 cites W2110894784 @default.
• W2022128299 cites W2110957729 @default.
• W2022128299 cites W2117551758 @default.
• W2022128299 cites W2118535812 @default.
• W2022128299 cites W2121055805 @default.
• W2022128299 cites W2121302081 @default.
• W2022128299 cites W2129107194 @default.
• W2022128299 cites W2133653334 @default.
• W2022128299 cites W2134459196 @default.
• W2022128299 cites W2140204965 @default.
• W2022128299 cites W2140513457 @default.
• W2022128299 cites W2140587516 @default.
• W2022128299 cites W2140626795 @default.
• W2022128299 cites W2141920998 @default.
• W2022128299 cites W2143658931 @default.
• W2022128299 cites W2144935474 @default.
• W2022128299 cites W2145155871 @default.
• W2022128299 cites W2145527883 @default.

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