FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022129281> ?p ?o ?g. }

• W2022129281 endingPage "7" @default.
• W2022129281 startingPage "1" @default.
• W2022129281 abstract "Amyloid protein can damage nerve cells through a variety of biological mechanisms including oxidative stress, alterations in calcium homeostasis, and proapoptosis. Edaravone, a potent free radical scavenger possessing antioxidant effects, has been proved neuroprotective effect in stroke patients. The current study aimed to investigate the effects of EDA in an A β -induced rat model of AD, by studying A β 1–40 -induced voltage-gated calcium channel currents in hippocampal CA1 pyramidal neurons, learning and memory behavioral tests, the number of surviving cholinergic neurons in the basal forebrain, and the acetylcholine level in the hippocampus in this rat model of AD. The results showed that the A β 1–40 -induced increase of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:msub><mml:mrow><mml:mi>I</mml:mi></mml:mrow><mml:mrow><mml:mtext>Ca</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>can be inhibited by EDA in a dose-dependent manner. Treatment with EDA significantly improved A β 1–40 -induced learning and memory performance. Choline acetyltransferase positive cells in basal forebrain and acetylcholine content in the hippocampus were increased by the administration of EDA as compared with the non-EDA treated A β 1–40 group. These results demonstrate that EDA can inhibit the neurotoxic effect of A β toxicity. Collectively, these findings suggest that EDA may serve as a potential complemental treatment strategy for AD." @default.
• W2022129281 created "2016-06-24" @default.
• W2022129281 creator A5027835055 @default.
• W2022129281 creator A5034826329 @default.
• W2022129281 creator A5046826953 @default.
• W2022129281 creator A5061076631 @default.
• W2022129281 creator A5075289507 @default.
• W2022129281 creator A5089930387 @default.
• W2022129281 date "2014-01-01" @default.
• W2022129281 modified "2023-10-14" @default.
• W2022129281 title "Inhibitory Effects of Edaravone in<i>β</i>-Amyloid-Induced Neurotoxicity in Rats" @default.
• W2022129281 cites W1604103060 @default.
• W2022129281 cites W1966894966 @default.
• W2022129281 cites W1986392423 @default.
• W2022129281 cites W1993019626 @default.
• W2022129281 cites W1993642608 @default.
• W2022129281 cites W2006422281 @default.
• W2022129281 cites W2008204888 @default.
• W2022129281 cites W2009830344 @default.
• W2022129281 cites W2012195082 @default.
• W2022129281 cites W2013362607 @default.
• W2022129281 cites W2022925950 @default.
• W2022129281 cites W2026168325 @default.
• W2022129281 cites W2026410063 @default.
• W2022129281 cites W2034454495 @default.
• W2022129281 cites W2034667072 @default.
• W2022129281 cites W2035329318 @default.
• W2022129281 cites W2075041489 @default.
• W2022129281 cites W2077518495 @default.
• W2022129281 cites W2083770406 @default.
• W2022129281 cites W2087485309 @default.
• W2022129281 cites W2091195476 @default.
• W2022129281 cites W2091564559 @default.
• W2022129281 cites W2103169804 @default.
• W2022129281 cites W2134672868 @default.
• W2022129281 doi "https://doi.org/10.1155/2014/370368" @default.
• W2022129281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3996961" @default.
• W2022129281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24804216" @default.
• W2022129281 hasPublicationYear "2014" @default.
• W2022129281 type Work @default.
• W2022129281 sameAs 2022129281 @default.
• W2022129281 citedByCount "18" @default.
• W2022129281 countsByYear W20221292812015 @default.
• W2022129281 countsByYear W20221292812016 @default.
• W2022129281 countsByYear W20221292812017 @default.
• W2022129281 countsByYear W20221292812018 @default.
• W2022129281 countsByYear W20221292812019 @default.
• W2022129281 countsByYear W20221292812020 @default.
• W2022129281 countsByYear W20221292812021 @default.
• W2022129281 countsByYear W20221292812023 @default.
• W2022129281 crossrefType "journal-article" @default.
• W2022129281 hasAuthorship W2022129281A5027835055 @default.
• W2022129281 hasAuthorship W2022129281A5034826329 @default.
• W2022129281 hasAuthorship W2022129281A5046826953 @default.
• W2022129281 hasAuthorship W2022129281A5061076631 @default.
• W2022129281 hasAuthorship W2022129281A5075289507 @default.
• W2022129281 hasAuthorship W2022129281A5089930387 @default.
• W2022129281 hasBestOaLocation W20221292811 @default.
• W2022129281 hasConcept C104966671 @default.
• W2022129281 hasConcept C126322002 @default.
• W2022129281 hasConcept C148762608 @default.
• W2022129281 hasConcept C185592680 @default.
• W2022129281 hasConcept C22885893 @default.
• W2022129281 hasConcept C25498285 @default.
• W2022129281 hasConcept C2775910092 @default.
• W2022129281 hasConcept C2776151105 @default.
• W2022129281 hasConcept C2776287375 @default.
• W2022129281 hasConcept C2779491297 @default.
• W2022129281 hasConcept C2779554857 @default.
• W2022129281 hasConcept C2781161787 @default.
• W2022129281 hasConcept C29730261 @default.
• W2022129281 hasConcept C2992339995 @default.
• W2022129281 hasConcept C55493867 @default.
• W2022129281 hasConcept C71924100 @default.
• W2022129281 hasConcept C98274493 @default.
• W2022129281 hasConceptScore W2022129281C104966671 @default.
• W2022129281 hasConceptScore W2022129281C126322002 @default.
• W2022129281 hasConceptScore W2022129281C148762608 @default.
• W2022129281 hasConceptScore W2022129281C185592680 @default.
• W2022129281 hasConceptScore W2022129281C22885893 @default.
• W2022129281 hasConceptScore W2022129281C25498285 @default.
• W2022129281 hasConceptScore W2022129281C2775910092 @default.
• W2022129281 hasConceptScore W2022129281C2776151105 @default.
• W2022129281 hasConceptScore W2022129281C2776287375 @default.
• W2022129281 hasConceptScore W2022129281C2779491297 @default.
• W2022129281 hasConceptScore W2022129281C2779554857 @default.
• W2022129281 hasConceptScore W2022129281C2781161787 @default.
• W2022129281 hasConceptScore W2022129281C29730261 @default.
• W2022129281 hasConceptScore W2022129281C2992339995 @default.
• W2022129281 hasConceptScore W2022129281C55493867 @default.
• W2022129281 hasConceptScore W2022129281C71924100 @default.
• W2022129281 hasConceptScore W2022129281C98274493 @default.
• W2022129281 hasFunder F4320321001 @default.
• W2022129281 hasLocation W20221292811 @default.
• W2022129281 hasLocation W20221292812 @default.
• W2022129281 hasLocation W20221292813 @default.
• W2022129281 hasLocation W20221292814 @default.
• W2022129281 hasLocation W20221292815 @default.

• next