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• W2022131093 abstract "Exposure to environmental endocrine-disrupting chemicals during pregnancy reportedly causes transgenerationally inherited reproductive defects. We hypothesized that to affect the grandchild, endocrine-disrupting chemicals must alter the epigenome of the germ cells of the in utero-exposed G1 male fetus. Additionally, to affect the great-grandchild, the aberration must persist in the germ cells of the unexposed G2 grandchild. Here, we treat gestating female mice with vinclozolin, bisphenol A, or di-(2-ethylhexyl)phthalate during the time when global de novo DNA methylation and imprint establishment occurs in the germ cells of the G1 male fetus. We map genome-wide features in purified G1 and G2 prospermatogonia, in order to detect immediate and persistent epigenetic aberrations, respectively. We detect changes in transcription and methylation in the G1 germline immediately after endocrine-disrupting chemicals exposure, but changes do not persist into the G2 germline. Additional analysis of genomic imprints shows no persistent aberrations in DNA methylation at the differentially methylated regions of imprinted genes between the G1 and G2 prospermatogonia, or in the allele-specific transcription of imprinted genes between the G2 and G3 soma. Our results suggest that endocrine-disrupting chemicals exert direct epigenetic effects in exposed fetal germ cells, which are corrected by reprogramming events in the next generation. Avoiding transgenerational inheritance of environmentally-caused epigenetic aberrations may have played an evolutionary role in the development of dual waves of global epigenome reprogramming in mammals." @default.
• W2022131093 created "2016-06-24" @default.
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• W2022131093 date "2015-03-27" @default.
• W2022131093 modified "2023-10-02" @default.
• W2022131093 title "Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming" @default.
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• W2022131093 cites W1976227891 @default.
• W2022131093 cites W1976935056 @default.
• W2022131093 cites W1979868295 @default.
• W2022131093 cites W1984944970 @default.
• W2022131093 cites W1986418330 @default.
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• W2022131093 cites W2034871574 @default.
• W2022131093 cites W2040558970 @default.
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• W2022131093 doi "https://doi.org/10.1186/s13059-015-0619-z" @default.
• W2022131093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4376074" @default.
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