FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022131604> ?p ?o ?g. }

• W2022131604 endingPage "229" @default.
• W2022131604 startingPage "226" @default.
• W2022131604 abstract "Opiates are widely used analgesics in anesthesiology, but they have serious adverse effects such as depression of breathing. This is caused by direct inhibition of rhythm-generating respiratory neurons in the Pre-Boetzinger complex (PBC) of the brainstem. We report that serotonin 4(a) [5-HT4(a)] receptors are strongly expressed in respiratory PBC neurons and that their selective activation protects spontaneous respiratory activity. Treatment of rats with a 5-HT4 receptor-specific agonist overcame fentanyl-induced respiratory depression and reestablished stable respiratory rhythm without loss of fentanyl's analgesic effect. These findings imply the prospect of a fine-tuned recovery from opioid-induced respiratory depression, through adjustment of intracellular adenosine 3',5'-monophosphate levels through the convergent signaling pathways in neurons." @default.
• W2022131604 created "2016-06-24" @default.
• W2022131604 creator A5009463515 @default.
• W2022131604 creator A5012211562 @default.
• W2022131604 creator A5021487531 @default.
• W2022131604 creator A5030410265 @default.
• W2022131604 creator A5045875920 @default.
• W2022131604 creator A5064688633 @default.
• W2022131604 creator A5086715926 @default.
• W2022131604 date "2003-07-11" @default.
• W2022131604 modified "2023-10-14" @default.
• W2022131604 title "5-HT _4(a) Receptors Avert Opioid-Induced Breathing Depression Without Loss of Analgesia" @default.
• W2022131604 cites W1965063801 @default.
• W2022131604 cites W1980468946 @default.
• W2022131604 cites W1993425462 @default.
• W2022131604 cites W2000744528 @default.
• W2022131604 cites W2030759164 @default.
• W2022131604 cites W2037233574 @default.
• W2022131604 cites W2037688283 @default.
• W2022131604 cites W2041734573 @default.
• W2022131604 cites W2047600489 @default.
• W2022131604 cites W2076494387 @default.
• W2022131604 cites W2077632155 @default.
• W2022131604 cites W2085493486 @default.
• W2022131604 cites W2100156006 @default.
• W2022131604 cites W2101199014 @default.
• W2022131604 cites W2132984603 @default.
• W2022131604 cites W2149464494 @default.
• W2022131604 cites W2151527826 @default.
• W2022131604 cites W4249570918 @default.
• W2022131604 doi "https://doi.org/10.1126/science.1084674" @default.
• W2022131604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12855812" @default.
• W2022131604 hasPublicationYear "2003" @default.
• W2022131604 type Work @default.
• W2022131604 sameAs 2022131604 @default.
• W2022131604 citedByCount "253" @default.
• W2022131604 countsByYear W20221316042012 @default.
• W2022131604 countsByYear W20221316042013 @default.
• W2022131604 countsByYear W20221316042014 @default.
• W2022131604 countsByYear W20221316042015 @default.
• W2022131604 countsByYear W20221316042016 @default.
• W2022131604 countsByYear W20221316042017 @default.
• W2022131604 countsByYear W20221316042018 @default.
• W2022131604 countsByYear W20221316042019 @default.
• W2022131604 countsByYear W20221316042020 @default.
• W2022131604 countsByYear W20221316042021 @default.
• W2022131604 countsByYear W20221316042022 @default.
• W2022131604 countsByYear W20221316042023 @default.
• W2022131604 crossrefType "journal-article" @default.
• W2022131604 hasAuthorship W2022131604A5009463515 @default.
• W2022131604 hasAuthorship W2022131604A5012211562 @default.
• W2022131604 hasAuthorship W2022131604A5021487531 @default.
• W2022131604 hasAuthorship W2022131604A5030410265 @default.
• W2022131604 hasAuthorship W2022131604A5045875920 @default.
• W2022131604 hasAuthorship W2022131604A5064688633 @default.
• W2022131604 hasAuthorship W2022131604A5086715926 @default.
• W2022131604 hasConcept C126322002 @default.
• W2022131604 hasConcept C139719470 @default.
• W2022131604 hasConcept C162324750 @default.
• W2022131604 hasConcept C170493617 @default.
• W2022131604 hasConcept C2775864247 @default.
• W2022131604 hasConcept C2776867660 @default.
• W2022131604 hasConcept C2778938600 @default.
• W2022131604 hasConcept C2781063702 @default.
• W2022131604 hasConcept C2781072394 @default.
• W2022131604 hasConcept C42219234 @default.
• W2022131604 hasConcept C534529494 @default.
• W2022131604 hasConcept C551621295 @default.
• W2022131604 hasConcept C71924100 @default.
• W2022131604 hasConcept C98274493 @default.
• W2022131604 hasConceptScore W2022131604C126322002 @default.
• W2022131604 hasConceptScore W2022131604C139719470 @default.
• W2022131604 hasConceptScore W2022131604C162324750 @default.
• W2022131604 hasConceptScore W2022131604C170493617 @default.
• W2022131604 hasConceptScore W2022131604C2775864247 @default.
• W2022131604 hasConceptScore W2022131604C2776867660 @default.
• W2022131604 hasConceptScore W2022131604C2778938600 @default.
• W2022131604 hasConceptScore W2022131604C2781063702 @default.
• W2022131604 hasConceptScore W2022131604C2781072394 @default.
• W2022131604 hasConceptScore W2022131604C42219234 @default.
• W2022131604 hasConceptScore W2022131604C534529494 @default.
• W2022131604 hasConceptScore W2022131604C551621295 @default.
• W2022131604 hasConceptScore W2022131604C71924100 @default.
• W2022131604 hasConceptScore W2022131604C98274493 @default.
• W2022131604 hasIssue "5630" @default.
• W2022131604 hasLocation W20221316041 @default.
• W2022131604 hasLocation W20221316042 @default.
• W2022131604 hasOpenAccess W2022131604 @default.
• W2022131604 hasPrimaryLocation W20221316041 @default.
• W2022131604 hasRelatedWork W1587680496 @default.
• W2022131604 hasRelatedWork W2001672425 @default.
• W2022131604 hasRelatedWork W2015668573 @default.
• W2022131604 hasRelatedWork W2027046282 @default.
• W2022131604 hasRelatedWork W2166994672 @default.
• W2022131604 hasRelatedWork W2326798145 @default.
• W2022131604 hasRelatedWork W2339682222 @default.
• W2022131604 hasRelatedWork W2368982121 @default.
• W2022131604 hasRelatedWork W4285735540 @default.

• next