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• W2022131661 endingPage "1372" @default.
• W2022131661 startingPage "1368" @default.
• W2022131661 abstract "Histoplasma capsulatum is an effective intracellular parasite of macrophages and causes the most prevalent fungal respiratory disease in the United States. A “dimorphic” fungus, H. capsulatum exists as a saprophytic mold in soil and converts to the parasitic yeast form after inhalation. Only the yeasts secrete a calcium-binding protein (CBP) and can grow in calcium-limiting conditions. To probe the relation between calcium limitation and intracellular parasitism, we designed a strategy to disrupt CBP1 in H. capsulatum using a telomeric linear plasmid and a two-step genetic selection. The resulting cbp1 yeasts no longer grew when deprived of calcium, and they were also unable to destroy macrophages in vitro or proliferate in a mouse model of pulmonary infection." @default.
• W2022131661 created "2016-06-24" @default.
• W2022131661 creator A5009544026 @default.
• W2022131661 creator A5050639231 @default.
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• W2022131661 date "2000-11-17" @default.
• W2022131661 modified "2023-09-23" @default.
• W2022131661 title "Intracellular Parasitism by <i>Histoplasma capsulatum</i> : Fungal Virulence and Calcium Dependence" @default.
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• W2022131661 doi "https://doi.org/10.1126/science.290.5495.1368" @default.
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• W2022131661 hasPublicationYear "2000" @default.
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