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• W2022132135 abstract "Abstract Philinopside A is a novel sulfated saponin isolated from the sea cucumber, Pentacta quadrangulari . The effects of philinopside A on angiogenesis and tumor growth were assessed in a series of models in vitro and in vivo . Our results demonstrated that philinopside A significantly inhibited the proliferation, migration and tube formation of human microvascular endothelial cells (HMECs) in a dose‐dependent manner, with average IC 50 values of 1.4 ± 0.17, 0.89 ± 0.23 and 0.98 ± 0.19 μM, respectively. Rat aortas culture assay provides a close imitation of in vivo angiogenesis process and 2–10 μM philinopside A suppressed the formation of new microvessels in cultured rat aortas. Philinopside A 2–10 nmol/egg obviously inhibited angiogenesis in chick embryo chorioallantoic membrane assay. In addition, philinopside A manifested strong anti‐tumor activities both in vitro and in vivo . Through immunofluorescent analysis, we found the compound reduced mouse sarcoma 180 tumor volume by inducing apoptosis of tumor and tumor‐associated endothelial cells. An examination of the effects of philinopside A on the angiogenesis‐related receptor tyrosine kinases (RTKs) showed that philinopside A broadly inhibited all tested RTKs, including vascular endothelial growth factor (VEGF) receptor, fibroblast growth factor (FGF) receptor‐1, platelet‐derived growth factor (PDGF) receptor‐β and epithelial growth factor (EGF) receptor, with IC 50 values ranging from 2.6–4.9 μM. These results suggest that philinopside A is a promising anti‐cancer agent that possesses dual cytotoxic and anti‐angiogenic effects that were at least partly due to its inhibitory effects on RTKs. © 2004 Wiley‐Liss, Inc." @default.
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• W2022132135 date "2005-01-11" @default.
• W2022132135 modified "2023-10-11" @default.
• W2022132135 title "Philinopside a, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects" @default.
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• W2022132135 doi "https://doi.org/10.1002/ijc.20804" @default.
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