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• W2022132303 abstract "The major obstacle to clinical development of siRNAs (short interfering RNAs), like for most of the nucleic-acid-based strategies, is their poor cellular uptake and bioavailability. Although several viral and non-viral strategies have been proposed to improve siRNA delivery, their applications in vivo remain a major challenge. We have developed a new strategy, based on a short amphipathic peptide, MPG, that is able to form stable nanoparticles with siRNA. MPG-based particles enter the cell independently of the endosomal pathway and can efficiently deliver siRNA in a fully biologically active form into a variety of cell lines and in vivo. This short review will discuss the mechanism and the potency of the MPG strategy for siRNA delivery both in vitro and in vivo." @default.
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• W2022132303 date "2007-01-22" @default.
• W2022132303 modified "2023-10-03" @default.
• W2022132303 title "A non-covalent peptide-based strategy for siRNA delivery" @default.
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• W2022132303 doi "https://doi.org/10.1042/bst0350044" @default.
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