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- W2022132839 abstract "Cyclic nucleotide-gated channels (CNGCs) on the dendritic cilia of olfactory receptor neurons (ORNs) are critical for sensory transduction in the olfactory system. Do CNGCs also play a role in the axons and/or nerve terminals of ORNs? We find that the cyclic nucleotides cAMP and cGMP can both facilitate and depress synaptic transmission between olfactory nerve fibers and their targets in olfactory bulb glomeruli. Cyclic nucleotides increase intracellular Ca(2+) in ORN terminals and enhance spontaneous transmitter release; at higher concentrations, cyclic nucleotides depress evoked transmission by altering olfactory nerve excitability. Cyclic nucleotides have no effect on transmission or nerve excitability, however, in mice lacking olfactory CNGCs. Taken together, our results identify a novel role for presynaptic CNGCs in modulating neurotransmission." @default.
- W2022132839 created "2016-06-24" @default.
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- W2022132839 creator A5068605154 @default.
- W2022132839 date "2003-02-01" @default.
- W2022132839 modified "2023-10-10" @default.
- W2022132839 title "Presynaptic Cyclic Nucleotide-Gated Ion Channels Modulate Neurotransmission in the Mammalian Olfactory Bulb" @default.
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- W2022132839 doi "https://doi.org/10.1016/s0896-6273(03)00057-6" @default.
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