Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022133196> ?p ?o ?g. }
- W2022133196 endingPage "10176" @default.
- W2022133196 startingPage "10171" @default.
- W2022133196 abstract "Glucokinase (GK) is a monomeric allosteric enzyme and plays a pivotal role in blood glucose homeostasis. GK is regulated by GK regulatory protein (GKRP), and indirectly by allosteric effectors of GKRP. Despite the critical roles of GK and GKRP, the molecular basis for the allosteric regulation mechanism of GK by GKRP remains unclear. We determined the crystal structure of Xenopus GK and GKRP complex in the presence of fructose-6-phosphate at 2.9 Å. GKRP binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK. We demonstrate the molecular mechanism for the modulation of GK activity by allosteric effectors of GKRP. Importantly, GKRP releases GK in a sigmoidal manner in response to glucose concentration by restricting a structural rearrangement of the GK small domain via a single ion pair. We find that GKRP acts as an allosteric switch for GK in blood glucose control by the liver." @default.
- W2022133196 created "2016-06-24" @default.
- W2022133196 creator A5008159288 @default.
- W2022133196 creator A5053282863 @default.
- W2022133196 creator A5065267721 @default.
- W2022133196 creator A5080783005 @default.
- W2022133196 creator A5085236560 @default.
- W2022133196 date "2013-06-03" @default.
- W2022133196 modified "2023-10-17" @default.
- W2022133196 title "Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase" @default.
- W2022133196 cites W1776600038 @default.
- W2022133196 cites W1792398103 @default.
- W2022133196 cites W1932966132 @default.
- W2022133196 cites W1964013137 @default.
- W2022133196 cites W1968280009 @default.
- W2022133196 cites W1971578664 @default.
- W2022133196 cites W1973375291 @default.
- W2022133196 cites W1982600501 @default.
- W2022133196 cites W1986278333 @default.
- W2022133196 cites W1999199961 @default.
- W2022133196 cites W2004340934 @default.
- W2022133196 cites W2005474992 @default.
- W2022133196 cites W2007569151 @default.
- W2022133196 cites W2015373835 @default.
- W2022133196 cites W2016161059 @default.
- W2022133196 cites W2018535049 @default.
- W2022133196 cites W2019717203 @default.
- W2022133196 cites W2022842991 @default.
- W2022133196 cites W2039379587 @default.
- W2022133196 cites W2045219326 @default.
- W2022133196 cites W2050605495 @default.
- W2022133196 cites W2051591857 @default.
- W2022133196 cites W2063527394 @default.
- W2022133196 cites W2075194050 @default.
- W2022133196 cites W2078272837 @default.
- W2022133196 cites W2091992338 @default.
- W2022133196 cites W2094173546 @default.
- W2022133196 cites W2108134904 @default.
- W2022133196 cites W2110763599 @default.
- W2022133196 cites W2112040506 @default.
- W2022133196 cites W2139991248 @default.
- W2022133196 cites W2149300333 @default.
- W2022133196 cites W2158590560 @default.
- W2022133196 cites W2164306929 @default.
- W2022133196 cites W2168493445 @default.
- W2022133196 cites W4235195764 @default.
- W2022133196 doi "https://doi.org/10.1073/pnas.1300457110" @default.
- W2022133196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3690866" @default.
- W2022133196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23733961" @default.
- W2022133196 hasPublicationYear "2013" @default.
- W2022133196 type Work @default.
- W2022133196 sameAs 2022133196 @default.
- W2022133196 citedByCount "62" @default.
- W2022133196 countsByYear W20221331962013 @default.
- W2022133196 countsByYear W20221331962014 @default.
- W2022133196 countsByYear W20221331962015 @default.
- W2022133196 countsByYear W20221331962016 @default.
- W2022133196 countsByYear W20221331962017 @default.
- W2022133196 countsByYear W20221331962018 @default.
- W2022133196 countsByYear W20221331962019 @default.
- W2022133196 countsByYear W20221331962020 @default.
- W2022133196 countsByYear W20221331962021 @default.
- W2022133196 countsByYear W20221331962022 @default.
- W2022133196 countsByYear W20221331962023 @default.
- W2022133196 crossrefType "journal-article" @default.
- W2022133196 hasAuthorship W2022133196A5008159288 @default.
- W2022133196 hasAuthorship W2022133196A5053282863 @default.
- W2022133196 hasAuthorship W2022133196A5065267721 @default.
- W2022133196 hasAuthorship W2022133196A5080783005 @default.
- W2022133196 hasAuthorship W2022133196A5085236560 @default.
- W2022133196 hasBestOaLocation W20221331961 @default.
- W2022133196 hasConcept C104317684 @default.
- W2022133196 hasConcept C109964505 @default.
- W2022133196 hasConcept C166342909 @default.
- W2022133196 hasConcept C181199279 @default.
- W2022133196 hasConcept C185592680 @default.
- W2022133196 hasConcept C2779535977 @default.
- W2022133196 hasConcept C51785407 @default.
- W2022133196 hasConcept C55493867 @default.
- W2022133196 hasConcept C86803240 @default.
- W2022133196 hasConcept C95444343 @default.
- W2022133196 hasConcept C98335778 @default.
- W2022133196 hasConceptScore W2022133196C104317684 @default.
- W2022133196 hasConceptScore W2022133196C109964505 @default.
- W2022133196 hasConceptScore W2022133196C166342909 @default.
- W2022133196 hasConceptScore W2022133196C181199279 @default.
- W2022133196 hasConceptScore W2022133196C185592680 @default.
- W2022133196 hasConceptScore W2022133196C2779535977 @default.
- W2022133196 hasConceptScore W2022133196C51785407 @default.
- W2022133196 hasConceptScore W2022133196C55493867 @default.
- W2022133196 hasConceptScore W2022133196C86803240 @default.
- W2022133196 hasConceptScore W2022133196C95444343 @default.
- W2022133196 hasConceptScore W2022133196C98335778 @default.
- W2022133196 hasIssue "25" @default.
- W2022133196 hasLocation W20221331961 @default.
- W2022133196 hasLocation W20221331962 @default.
- W2022133196 hasLocation W20221331963 @default.
- W2022133196 hasLocation W20221331964 @default.