FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022133633> ?p ?o ?g. }

• W2022133633 endingPage "2476" @default.
• W2022133633 startingPage "2467" @default.
• W2022133633 abstract "The developing central nervous system is partitioned into compartments by boundary cells, which have different properties than compartment cells, such as forming neuron-free zones, proliferating more slowly and acting as organizing centers. We now report that in mice the bHLH factor Hes1 is persistently expressed at high levels by boundary cells but at variable levels by non-boundary cells. Expression levels of Hes1 display an inverse correlation to those of the proneural bHLH factor Mash1, suggesting that downregulation of Hes1 leads to upregulation of Mash1 in non-boundary regions,whereas persistent and high Hes1 expression constitutively represses Mash1 in boundary regions. In agreement with this notion, in the absence of Hes1 and its related genes Hes3 and Hes5, proneural bHLH genes are ectopically expressed in boundaries, resulting in ectopic neurogenesis and disruption of the organizing centers. Conversely, persistent Hes1 expression in neural progenitors prepared from compartment regions blocks neurogenesis and reduces cell proliferation rates. These results indicate that the mode of Hes1 expression is different between boundary and non-boundary cells, and that persistent and high levels of Hes1 expression constitutively repress proneural bHLH gene expression and reduce cell proliferation rates,thereby forming boundaries that act as the organizing centers." @default.
• W2022133633 created "2016-06-24" @default.
• W2022133633 creator A5014103535 @default.
• W2022133633 creator A5018917055 @default.
• W2022133633 creator A5031048743 @default.
• W2022133633 creator A5033165469 @default.
• W2022133633 creator A5058687045 @default.
• W2022133633 date "2006-07-01" @default.
• W2022133633 modified "2023-10-16" @default.
• W2022133633 title "Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system" @default.
• W2022133633 cites W1499659548 @default.
• W2022133633 cites W1596939807 @default.
• W2022133633 cites W1618939505 @default.
• W2022133633 cites W1658437261 @default.
• W2022133633 cites W1965632185 @default.
• W2022133633 cites W1971272788 @default.
• W2022133633 cites W1972079160 @default.
• W2022133633 cites W1977300801 @default.
• W2022133633 cites W1980756779 @default.
• W2022133633 cites W1992383169 @default.
• W2022133633 cites W1993246319 @default.
• W2022133633 cites W1993736057 @default.
• W2022133633 cites W1994666066 @default.
• W2022133633 cites W1994859370 @default.
• W2022133633 cites W2005588884 @default.
• W2022133633 cites W2014077626 @default.
• W2022133633 cites W2017878349 @default.
• W2022133633 cites W2021766626 @default.
• W2022133633 cites W2025748388 @default.
• W2022133633 cites W2025804504 @default.
• W2022133633 cites W2026613468 @default.
• W2022133633 cites W2027088025 @default.
• W2022133633 cites W2032794576 @default.
• W2022133633 cites W2038059446 @default.
• W2022133633 cites W2039766969 @default.
• W2022133633 cites W2048389644 @default.
• W2022133633 cites W2059789358 @default.
• W2022133633 cites W2061191160 @default.
• W2022133633 cites W2068867464 @default.
• W2022133633 cites W2069957508 @default.
• W2022133633 cites W2072325944 @default.
• W2022133633 cites W2077780809 @default.
• W2022133633 cites W2078126797 @default.
• W2022133633 cites W2080783854 @default.
• W2022133633 cites W2081996545 @default.
• W2022133633 cites W2083904307 @default.
• W2022133633 cites W2088969512 @default.
• W2022133633 cites W2092017486 @default.
• W2022133633 cites W2095410611 @default.
• W2022133633 cites W2106921662 @default.
• W2022133633 cites W2115692032 @default.
• W2022133633 cites W2127587858 @default.
• W2022133633 cites W2128650008 @default.
• W2022133633 cites W2129415104 @default.
• W2022133633 cites W2137134568 @default.
• W2022133633 cites W2142940829 @default.
• W2022133633 cites W2144458244 @default.
• W2022133633 cites W2151481394 @default.
• W2022133633 cites W2157969772 @default.
• W2022133633 cites W2159527243 @default.
• W2022133633 cites W2160346415 @default.
• W2022133633 cites W2166529745 @default.
• W2022133633 cites W2312829076 @default.
• W2022133633 cites W4229950153 @default.
• W2022133633 doi "https://doi.org/10.1242/dev.02403" @default.
• W2022133633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16728479" @default.
• W2022133633 hasPublicationYear "2006" @default.
• W2022133633 type Work @default.
• W2022133633 sameAs 2022133633 @default.
• W2022133633 citedByCount "196" @default.
• W2022133633 countsByYear W20221336332012 @default.
• W2022133633 countsByYear W20221336332013 @default.
• W2022133633 countsByYear W20221336332014 @default.
• W2022133633 countsByYear W20221336332015 @default.
• W2022133633 countsByYear W20221336332016 @default.
• W2022133633 countsByYear W20221336332017 @default.
• W2022133633 countsByYear W20221336332018 @default.
• W2022133633 countsByYear W20221336332019 @default.
• W2022133633 countsByYear W20221336332020 @default.
• W2022133633 countsByYear W20221336332021 @default.
• W2022133633 countsByYear W20221336332022 @default.
• W2022133633 countsByYear W20221336332023 @default.
• W2022133633 crossrefType "journal-article" @default.
• W2022133633 hasAuthorship W2022133633A5014103535 @default.
• W2022133633 hasAuthorship W2022133633A5018917055 @default.
• W2022133633 hasAuthorship W2022133633A5031048743 @default.
• W2022133633 hasAuthorship W2022133633A5033165469 @default.
• W2022133633 hasAuthorship W2022133633A5058687045 @default.
• W2022133633 hasBestOaLocation W20221336332 @default.
• W2022133633 hasConcept C104317684 @default.
• W2022133633 hasConcept C111368507 @default.
• W2022133633 hasConcept C127313418 @default.
• W2022133633 hasConcept C127561419 @default.
• W2022133633 hasConcept C161879069 @default.
• W2022133633 hasConcept C201750760 @default.
• W2022133633 hasConcept C203635412 @default.
• W2022133633 hasConcept C2780283210 @default.
• W2022133633 hasConcept C28328180 @default.

• next