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- W2022133675 abstract "The aim of this study was to investigate the effect of water-soluble macromolecular components of Artemisia capillaris Thunberg (ACT) on human hepatoma cell line SMMC-7721 (SMMC-7721). The morphological changes of SMMC-7721 were observed under a light microscope and an electron microscope. Inhibition of proliferation was measured with a colorimetric MTT assay. It was discovered that ACT extract-treated cells exhibit morphological changes typical of apoptosis, including condensed chromatin and a reduction in volume. ACT extract at 25-200 microg/ml dose-dependently inhibited the proliferation of SMMC-7721. The 50% effective dose, evaluated on day 3 of exposure to the extract, was 64.52+/-3.53 microg/ml. Upon gel electrophoresis, the fragmented DNA showed a characteristic ladder pattern. Cell cycle analyses revealed that ACT induced cell cycle arrest at the G0/G1 phase." @default.
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- W2022133675 date "2000-01-01" @default.
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- W2022133675 title "Apoptosis in Human Hepatoma Cell Line SMMC-7721 Induced by Water-soluble Macromolecular Components of<i>Artemisia capillaris</i>Thunberg" @default.
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- W2022133675 doi "https://doi.org/10.1111/j.1349-7006.2000.tb00867.x" @default.
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