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• W2022133986 abstract "Primases synthesize the RNA primers that are necessary for replication of the parental DNA strands. Here we report that the heterodimeric archaeal/eukaryotic primase is an iron-sulfur (Fe-S) protein. Binding of the Fe-S cluster is mediated by an evolutionarily conserved domain at the C terminus of the large subunit. We further show that the Fe-S domain is essential to the unique ability of the eukaryotic primase to start DNA replication." @default.
• W2022133986 created "2016-06-24" @default.
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• W2022133986 date "2007-08-19" @default.
• W2022133986 modified "2023-10-15" @default.
• W2022133986 title "An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis" @default.
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• W2022133986 doi "https://doi.org/10.1038/nsmb1288" @default.
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