Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022135231> ?p ?o ?g. }
- W2022135231 endingPage "1148" @default.
- W2022135231 startingPage "1139" @default.
- W2022135231 abstract "Abstract Generating efficient antibody (Ab) responses against weak antigens remains challenging. Ab responses require antigen (Ag) uptake by antigen‐presenting cells (APC), followed by presentation of processed Ag to T cells. Limited uptake of antigenic peptides by APC constrains Ab responses. Here we improve vaccine efficacy by targeting Ag to Fcγ receptors (FcγR) using R4, a recombinant FcγR ligand. R4 has four repeats per chain of the hinge region and CH2 domain (HCH2) of human IgG1. HCH2 encompasses the FcγR binding site. The repeats are linked to the human IgG1 framework. To test R4 in augmenting Ag uptake, we expressed human serum albumin domain 1 (HSA1) at the N terminus of R4 to produce HSA1R4. HSA1R4 (50 μg) administered to mice in Ribi adjuvant induces up to 1100‐fold higher HSA1‐specific IgG titers than HSA1 ( p <0.001). HSA1R4 (250 ng) induces up to 130 times more anti‐HSA1 Ab than HSA1Fc, a protein with HSA1 linked to the IgG1 framework ( p <0.001). HSA‐reactive T cells proliferate more briskly to HSA1R4 than to HSA1Fc ( p <0.008). Immunization with HSA1R4 yields greater T cell reactivity to HSA1 ex vivo than immunization with HSA1Fc ( p <0.004). Linking antigenic peptides to linear HCH2 polymers may facilitate vaccine development." @default.
- W2022135231 created "2016-06-24" @default.
- W2022135231 creator A5031496798 @default.
- W2022135231 creator A5042335053 @default.
- W2022135231 creator A5058291383 @default.
- W2022135231 date "2007-03-28" @default.
- W2022135231 modified "2023-10-18" @default.
- W2022135231 title "A novel Fcγ receptor ligand augments humoral responses by targeting antigen to Fcγ receptors" @default.
- W2022135231 cites W1482080671 @default.
- W2022135231 cites W1494228633 @default.
- W2022135231 cites W1502725684 @default.
- W2022135231 cites W1507548252 @default.
- W2022135231 cites W1530930152 @default.
- W2022135231 cites W1895905470 @default.
- W2022135231 cites W1944996883 @default.
- W2022135231 cites W1964706714 @default.
- W2022135231 cites W1967780364 @default.
- W2022135231 cites W1971349333 @default.
- W2022135231 cites W1976394313 @default.
- W2022135231 cites W1977631644 @default.
- W2022135231 cites W1979127206 @default.
- W2022135231 cites W1981952372 @default.
- W2022135231 cites W1982895831 @default.
- W2022135231 cites W1990827960 @default.
- W2022135231 cites W2002411614 @default.
- W2022135231 cites W2005098984 @default.
- W2022135231 cites W2006790167 @default.
- W2022135231 cites W2016708646 @default.
- W2022135231 cites W2022409370 @default.
- W2022135231 cites W2024606709 @default.
- W2022135231 cites W2027178598 @default.
- W2022135231 cites W2035439001 @default.
- W2022135231 cites W2043304777 @default.
- W2022135231 cites W2061268459 @default.
- W2022135231 cites W2073821671 @default.
- W2022135231 cites W2081717004 @default.
- W2022135231 cites W2084743858 @default.
- W2022135231 cites W2086252967 @default.
- W2022135231 cites W2086542713 @default.
- W2022135231 cites W2092545878 @default.
- W2022135231 cites W2114949839 @default.
- W2022135231 cites W2128519954 @default.
- W2022135231 cites W2130867278 @default.
- W2022135231 cites W2151660552 @default.
- W2022135231 cites W2154901790 @default.
- W2022135231 cites W2159029707 @default.
- W2022135231 cites W2170736102 @default.
- W2022135231 cites W3026223749 @default.
- W2022135231 cites W4294216491 @default.
- W2022135231 cites W4313347699 @default.
- W2022135231 doi "https://doi.org/10.1002/eji.200636321" @default.
- W2022135231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17393382" @default.
- W2022135231 hasPublicationYear "2007" @default.
- W2022135231 type Work @default.
- W2022135231 sameAs 2022135231 @default.
- W2022135231 citedByCount "7" @default.
- W2022135231 countsByYear W20221352312012 @default.
- W2022135231 countsByYear W20221352312014 @default.
- W2022135231 countsByYear W20221352312016 @default.
- W2022135231 crossrefType "journal-article" @default.
- W2022135231 hasAuthorship W2022135231A5031496798 @default.
- W2022135231 hasAuthorship W2022135231A5042335053 @default.
- W2022135231 hasAuthorship W2022135231A5058291383 @default.
- W2022135231 hasConcept C104317684 @default.
- W2022135231 hasConcept C147483822 @default.
- W2022135231 hasConcept C150903083 @default.
- W2022135231 hasConcept C153911025 @default.
- W2022135231 hasConcept C159654299 @default.
- W2022135231 hasConcept C170493617 @default.
- W2022135231 hasConcept C203014093 @default.
- W2022135231 hasConcept C207001950 @default.
- W2022135231 hasConcept C2777863537 @default.
- W2022135231 hasConcept C32611913 @default.
- W2022135231 hasConcept C40767141 @default.
- W2022135231 hasConcept C55493867 @default.
- W2022135231 hasConcept C86803240 @default.
- W2022135231 hasConceptScore W2022135231C104317684 @default.
- W2022135231 hasConceptScore W2022135231C147483822 @default.
- W2022135231 hasConceptScore W2022135231C150903083 @default.
- W2022135231 hasConceptScore W2022135231C153911025 @default.
- W2022135231 hasConceptScore W2022135231C159654299 @default.
- W2022135231 hasConceptScore W2022135231C170493617 @default.
- W2022135231 hasConceptScore W2022135231C203014093 @default.
- W2022135231 hasConceptScore W2022135231C207001950 @default.
- W2022135231 hasConceptScore W2022135231C2777863537 @default.
- W2022135231 hasConceptScore W2022135231C32611913 @default.
- W2022135231 hasConceptScore W2022135231C40767141 @default.
- W2022135231 hasConceptScore W2022135231C55493867 @default.
- W2022135231 hasConceptScore W2022135231C86803240 @default.
- W2022135231 hasIssue "4" @default.
- W2022135231 hasLocation W20221352311 @default.
- W2022135231 hasLocation W20221352312 @default.
- W2022135231 hasOpenAccess W2022135231 @default.
- W2022135231 hasPrimaryLocation W20221352311 @default.
- W2022135231 hasRelatedWork W1542522870 @default.
- W2022135231 hasRelatedWork W2021792849 @default.
- W2022135231 hasRelatedWork W2027670370 @default.
- W2022135231 hasRelatedWork W2107405807 @default.