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• W2022135795 endingPage "1372" @default.
• W2022135795 startingPage "1360" @default.
• W2022135795 abstract "Pancreatic cancer has a dismal 5 year survival rate of 5.5% that has not been improved over the past 25 years despite an enormous amount of effort. Thus, there is an urgent need to identify truly novel yet druggable protein targets for drug discovery. The human protein DnaJ homologue subfamily A member 1 (DNAJA1) was previously shown to be downregulated 5-fold in pancreatic cancer cells and has been targeted as a biomarker for pancreatic cancer, but little is known about the specific biological function for DNAJA1 or the other members of the DnaJ family encoded in the human genome. Our results suggest the overexpression of DNAJA1 suppresses the stress response capabilities of the oncogenic transcription factor, c-Jun, and results in the diminution of cell survival. DNAJA1 likely activates a DnaK protein by forming a complex that suppresses the JNK pathway, the hyperphosphorylation of c-Jun, and the anti-apoptosis state found in pancreatic cancer cells. A high-quality nuclear magnetic resonance solution structure of the J-domain of DNAJA1 combined with a bioinformatics analysis and a ligand affinity screen identifies a potential DnaK binding site, which is also predicted to overlap with an inhibitory binding site, suggesting DNAJA1 activity is highly regulated." @default.
• W2022135795 created "2016-06-24" @default.
• W2022135795 creator A5016524389 @default.
• W2022135795 creator A5028579654 @default.
• W2022135795 creator A5044542421 @default.
• W2022135795 creator A5046496562 @default.
• W2022135795 creator A5060280196 @default.
• W2022135795 creator A5061550044 @default.
• W2022135795 creator A5067292361 @default.
• W2022135795 creator A5079624314 @default.
• W2022135795 date "2014-02-19" @default.
• W2022135795 modified "2023-10-18" @default.
• W2022135795 title "Structure and Function of Human DnaJ Homologue Subfamily A Member 1 (DNAJA1) and Its Relationship to Pancreatic Cancer" @default.
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