Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022136250> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2022136250 endingPage "134" @default.
- W2022136250 startingPage "134" @default.
- W2022136250 abstract "Familial amyloidotic polyneuropathy (FAP) is a late‐onset inherited disease characterized by the deposition of amyloid fibrils. FAP is associated with mutations on the transthyretin (TTR) gene. A monoclonal antibody, MAb 39‐44, reacting with high molecular weight aggregates of TTR but not with tetrameric TTR has recently been generated and characterized. This antibody recognizes a cryptic epitope that is expressed in isolated recombinant amyloidogenic mutants and in ex vivo amyloid. In the present work we show that this amyloid‐specific antibody specifically recognizes in a direct enzyme‐linked immunoassay (ELISA) plasma TTR from carriers of various mutations associated with FAP, both in asymptomatic individuals and in patients. In contrast, it does not react with plasma TTR from healthy individuals or that from carriers of nonpathogenic mutations. Using the ELISA developed in this study we identified three different TTR mutations in Portuguese patients with neuropathy of unknown cause, later shown to have amyloid tissue deposition. This antibody recognizes conformations that express cryptic epitopes shared by amyloidogenic TTR variants associated with FAP, not present among nonpathogenic TTR molecules. This antibody will contribute to further identify and characterize intermediates of the amyloidogenic cascade. In addition, it will also be useful for screening amyloidogenic TTR mutations in patients with neuropathy of unknown cause, prior to precise molecular diagnosis using protein and/or DNA analysis." @default.
- W2022136250 created "2016-06-24" @default.
- W2022136250 creator A5021195219 @default.
- W2022136250 creator A5022817762 @default.
- W2022136250 creator A5028650791 @default.
- W2022136250 creator A5038285273 @default.
- W2022136250 creator A5083377488 @default.
- W2022136250 date "2002-06-01" @default.
- W2022136250 modified "2023-09-25" @default.
- W2022136250 title "Antibody recognition of amyloidogenic transthyretin variants in serum of patients with familial amyloidotic polyneuropathy" @default.
- W2022136250 doi "https://doi.org/10.1046/j.1529-8027.2002.02011_1.x" @default.
- W2022136250 hasPublicationYear "2002" @default.
- W2022136250 type Work @default.
- W2022136250 sameAs 2022136250 @default.
- W2022136250 citedByCount "1" @default.
- W2022136250 countsByYear W20221362502020 @default.
- W2022136250 crossrefType "journal-article" @default.
- W2022136250 hasAuthorship W2022136250A5021195219 @default.
- W2022136250 hasAuthorship W2022136250A5022817762 @default.
- W2022136250 hasAuthorship W2022136250A5028650791 @default.
- W2022136250 hasAuthorship W2022136250A5038285273 @default.
- W2022136250 hasAuthorship W2022136250A5083377488 @default.
- W2022136250 hasConcept C104317684 @default.
- W2022136250 hasConcept C121157162 @default.
- W2022136250 hasConcept C142724271 @default.
- W2022136250 hasConcept C153911025 @default.
- W2022136250 hasConcept C159654299 @default.
- W2022136250 hasConcept C185592680 @default.
- W2022136250 hasConcept C195616568 @default.
- W2022136250 hasConcept C203014093 @default.
- W2022136250 hasConcept C2775892965 @default.
- W2022136250 hasConcept C2777633098 @default.
- W2022136250 hasConcept C2779951007 @default.
- W2022136250 hasConcept C40767141 @default.
- W2022136250 hasConcept C501734568 @default.
- W2022136250 hasConcept C542903549 @default.
- W2022136250 hasConcept C55493867 @default.
- W2022136250 hasConcept C71924100 @default.
- W2022136250 hasConcept C86803240 @default.
- W2022136250 hasConceptScore W2022136250C104317684 @default.
- W2022136250 hasConceptScore W2022136250C121157162 @default.
- W2022136250 hasConceptScore W2022136250C142724271 @default.
- W2022136250 hasConceptScore W2022136250C153911025 @default.
- W2022136250 hasConceptScore W2022136250C159654299 @default.
- W2022136250 hasConceptScore W2022136250C185592680 @default.
- W2022136250 hasConceptScore W2022136250C195616568 @default.
- W2022136250 hasConceptScore W2022136250C203014093 @default.
- W2022136250 hasConceptScore W2022136250C2775892965 @default.
- W2022136250 hasConceptScore W2022136250C2777633098 @default.
- W2022136250 hasConceptScore W2022136250C2779951007 @default.
- W2022136250 hasConceptScore W2022136250C40767141 @default.
- W2022136250 hasConceptScore W2022136250C501734568 @default.
- W2022136250 hasConceptScore W2022136250C542903549 @default.
- W2022136250 hasConceptScore W2022136250C55493867 @default.
- W2022136250 hasConceptScore W2022136250C71924100 @default.
- W2022136250 hasConceptScore W2022136250C86803240 @default.
- W2022136250 hasIssue "2" @default.
- W2022136250 hasLocation W20221362501 @default.
- W2022136250 hasOpenAccess W2022136250 @default.
- W2022136250 hasPrimaryLocation W20221362501 @default.
- W2022136250 hasRelatedWork W1500368728 @default.
- W2022136250 hasRelatedWork W1972798080 @default.
- W2022136250 hasRelatedWork W2003247625 @default.
- W2022136250 hasRelatedWork W2004547908 @default.
- W2022136250 hasRelatedWork W2084515092 @default.
- W2022136250 hasRelatedWork W2109513774 @default.
- W2022136250 hasRelatedWork W2149971709 @default.
- W2022136250 hasRelatedWork W2171621707 @default.
- W2022136250 hasRelatedWork W2316591432 @default.
- W2022136250 hasRelatedWork W304850061 @default.
- W2022136250 hasVolume "7" @default.
- W2022136250 isParatext "false" @default.
- W2022136250 isRetracted "false" @default.
- W2022136250 magId "2022136250" @default.
- W2022136250 workType "article" @default.