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• W2022137375 abstract "In situations that would be expected to induce regret, the authors report that rats looked backwards towards a lost option, the cells in OFC and ventral striatum represented that missed action, rats were more likely to wait out a long delay, and then they rushed through consuming rewards, suggesting that regret-like processes modify decision-making in nonhuman mammals. Disappointment entails the recognition that one did not get the value expected. In contrast, regret entails recognition that an alternative (counterfactual) action would have produced a more valued outcome. In humans, the orbitofrontal cortex is active during expressions of regret, and humans with damage to the orbitofrontal cortex do not express regret. In rats and nonhuman primates, both the orbitofrontal cortex and the ventral striatum have been implicated in reward computations. We recorded neural ensembles from orbitofrontal cortex and ventral striatum in rats encountering wait or skip choices for delayed delivery of different flavors using an economic framework. Economically, encountering a high-cost choice after skipping a low-cost choice should induce regret. In these situations, rats looked backwards toward the lost option, cells within orbitofrontal cortex and ventral striatum represented the missed action, rats were more likely to wait for the long delay, and rats rushed through eating the food after that delay." @default.
• W2022137375 created "2016-06-24" @default.
• W2022137375 creator A5030006518 @default.
• W2022137375 creator A5032363186 @default.
• W2022137375 date "2014-06-08" @default.
• W2022137375 modified "2023-09-27" @default.
• W2022137375 title "Behavioral and neurophysiological correlates of regret in rat decision-making on a neuroeconomic task" @default.
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• W2022137375 doi "https://doi.org/10.1038/nn.3740" @default.
• W2022137375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4113023" @default.
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