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- W2022137450 abstract "Abstract The problem of analysis strategies for adaptive designs with multiple endpoints is considered. We first provide a review of the commonly used methods for addressing the issue of multiplicity in classical designs, followed by the gatekeeper procedure and the fractal gatekeeper procedure. The latter will be applied to address the issue of multiplicity in adaptive trials with multiple endpoints based on the invariance property of the test statistic employed. Practical examples are presented to illustrate the proposed fractal gatekeeper method when analyzing data obtained from an adaptive trial with multiple endpoints. Key Words: Adaptive design with multiple endpointsClosed testing procedureFractal gatekeeper procedureGatekeeper procedureMultiplicity ACKNOWLEDGMENTS The authors wish to thank the review for the constructive comments and Dr. S. Yang, Dr. K. K. G. Lan, Dr. G. Chen, Dr. G. Chi, and Dr. S. J. Wang for the very inspired discussions on this topic." @default.
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- W2022137450 date "2007-11-08" @default.
- W2022137450 modified "2023-10-09" @default.
- W2022137450 title "Analysis Strategies for Adaptive Designs with Multiple Endpoints" @default.
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- W2022137450 doi "https://doi.org/10.1080/10543400701645348" @default.
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