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• W2022138421 abstract "Background and purpose Apathy may be either a symptom of major depression or a behavioral disturbance occurring in concomitance with depression or alone in Parkinson's disease ( PD ). The aim of the present study was to determine the progression of cognitive impairment in drug‐naïve untreated PD patients with or without clinically significant apathy. Methods Sixty‐two PD patients with a disease duration <2 years and without history of present or past therapy with pro‐dopaminergic agents were included and underwent the Apathy Evaluation Scale ( S ‐ AES ), a clinical interview based on diagnostic criteria for apathy and a comprehensive neuropsychological battery to assess memory, frontal functions and visuospatial functions. Two years after the first assessment, all patients were re‐evaluated on the S ‐ AES , a clinical interview and neuropsychological tests. Results According to the cut‐off value of the S ‐ AES and diagnostic criteria for apathy, eight patients experienced apathy at both baseline and follow‐up (A+A+), nine patients had apathy only at follow‐up (A−A+), 37 patients never experienced apathy (A−A−) and eight patients showed apathy at the baseline only (A+A−). Cognitive performance significantly declined in all four groups. At both baseline and follow‐up A+A+ performed worse than A−A− on visuospatial and frontal tests; A−A+ had lower scores than A−A− on the interference task of the Stroop test ( IT ‐ ST ). Regression analysis showed that poor performance on the IT ‐ ST at baseline was the only independent predictor of onset of apathy at follow‐up. Conclusions The results indicated a relationship between apathy and dysexecutive syndrome in early PD . Reduced scores on the IT ‐ ST may predict development of apathy in PD patients." @default.
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• W2022138421 date "2014-05-22" @default.
• W2022138421 modified "2023-09-27" @default.
• W2022138421 title "Relationship between apathy and cognitive dysfunctions in<i>de novo</i>untreated Parkinson's disease: a prospective longitudinal study" @default.
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• W2022138421 doi "https://doi.org/10.1111/ene.12467" @default.
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