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- W2022140142 endingPage "1338" @default.
- W2022140142 startingPage "1318" @default.
- W2022140142 abstract "Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. Many promoters in embryonic stem (ES) cells harbor a distinctive histone modification signature that combines the activating histone H3 Lys 4 trimethylation (H3K4me3) mark and the repressive H3K27me3 mark. These bivalent domains are considered to poise expression of developmental genes, allowing timely activation while maintaining repression in the absence of differentiation signals. Recent advances shed light on the establishment and function of bivalent domains; however, their role in development remains controversial, not least because suitable genetic models to probe their function in developing organisms are missing. Here, we explore avenues to and from bivalency and propose that bivalent domains and associated chromatin-modifying complexes safeguard proper and robust differentiation." @default.
- W2022140142 created "2016-06-24" @default.
- W2022140142 creator A5016384926 @default.
- W2022140142 creator A5053760914 @default.
- W2022140142 creator A5058461013 @default.
- W2022140142 date "2013-06-15" @default.
- W2022140142 modified "2023-10-16" @default.
- W2022140142 title "A double take on bivalent promoters" @default.
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