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- W2022141048 abstract "In 16 patients with hypertension, BP could not be controlled satisfactorily by treatment with propranolol alone (mean dosage 325 mg/day). Plasma volume (PV) (T-1824) and extracellular fluid volume (ECV) (82Br-distribution space) were determined in these patients before and after the addition of hydralazine for three months (mean dosage 135 mg/day). After the addition of hydralazine, PV and ECV increased significantly, by 9% and 3%, respectively. Systolic and diastolic BPs decreased, by 15% and 13%. The mechanisms inducing fluid retention during treatment with hydralazine and the clinical significance of the problem are discussed. It is concluded that the addition of a diuretic to propranolol-hydralazine treatment is often well indicated." @default.
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- W2022141048 date "1978-01-12" @default.
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- W2022141048 title "Changes in Plasma Volume and Extracellular Fluid Volume after Addition of Hydralazine to Propranolol Treatment in Patients with Hypertension" @default.
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- W2022141048 doi "https://doi.org/10.1111/j.0954-6820.1978.tb14899.x" @default.
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