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- W2022141581 endingPage "63" @default.
- W2022141581 startingPage "54" @default.
- W2022141581 abstract "The insulin-like growth factors (IGF-I and -II) are potent mitogens and survival factors for both normal and malignant breast cells. These effects are mediated primarily through the IGF-I receptor (IGF-IR), which is significantly overexpressed and highly activated in breast tumors. The IGF-binding proteins are competitive inhibitors of IGF/IGF-IR interaction, limiting cellular proliferation and survival. Higher serum IGF-I levels or an increased ratio of IGF-I to IGF binding protein-3 is associated with an increased risk of developing breast cancer. Hence, interest in the IGF system as a potential target for the development of novel antineoplastic therapies has ensued. Several strategies to interrupt IGF-IR signaling are currently being evaluated for the treatment of breast cancer, including suppression of IGF production, reduction of functional IGF-IR levels, neutralization of IGF action, and inhibition of IGF-IR activation." @default.
- W2022141581 created "2016-06-24" @default.
- W2022141581 creator A5046095564 @default.
- W2022141581 creator A5067911029 @default.
- W2022141581 creator A5068271757 @default.
- W2022141581 date "2004-02-01" @default.
- W2022141581 modified "2023-09-26" @default.
- W2022141581 title "Anti-insulin-like growth factor strategies in breast cancer" @default.
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- W2022141581 doi "https://doi.org/10.1053/j.seminoncol.2004.01.007" @default.
- W2022141581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15052543" @default.
- W2022141581 hasPublicationYear "2004" @default.
- W2022141581 type Work @default.