FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022143119> ?p ?o ?g. }

• W2022143119 endingPage "149" @default.
• W2022143119 startingPage "142" @default.
• W2022143119 abstract "Exposure to intense, acute-stressors modulates immune function. We have previously reported, for example, that exposure to a single session of inescapable tailshock suppresses acquired and potentiates innate immune responses mediated by the spleen. The mechanisms for these changes remain unknown, however, they likely involve stress-induced modulation of cytokines. Cytokines operate in coordinated networks that include other immunoregulatory factors. Broad-scoped analyses are required to gain an understanding of the net-impact of stress on these immunoregulatory factors and the immune system. The goal of this study, therefore, is to examine the impact of acute-stressor exposure on network-wide changes in splenic immunoregulatory factor expression. One hundred and sixty-one genes linked to innate immune responses were quantified in the spleen following exposure to tailshock using an RT-PCR based gene array. Expression changes in 17 of the measured genes were confirmed using individual RT-PCR reactions. Further assessment of the expression changes using Exploratory Gene Association Networks (EGAN) identified important ontologies, processes and pathways that are indicative of a broader impact of stress on the immune system. Interestingly, EGAN identified several linkages between immunoregulatory factors that may be important in explaining previous results concerning the functional consequences of stress on splenic immunity. Additional processes, some of which are novel to this study, were also uncovered that may be important in directing future studies examining the impact of stress on the immune system. In this way, these analyses provide a better understanding of how acute stressor exposure modulates splenic immunity and may function as predictive tool for future related studies." @default.
• W2022143119 created "2016-06-24" @default.
• W2022143119 creator A5033720615 @default.
• W2022143119 creator A5040373664 @default.
• W2022143119 creator A5041641869 @default.
• W2022143119 creator A5054903943 @default.
• W2022143119 date "2012-01-01" @default.
• W2022143119 modified "2023-10-17" @default.
• W2022143119 title "The impact of acute-stressor exposure on splenic innate immunity: A gene expression analysis" @default.
• W2022143119 cites W1536660914 @default.
• W2022143119 cites W1964518559 @default.
• W2022143119 cites W1966672895 @default.
• W2022143119 cites W1975437647 @default.
• W2022143119 cites W1981187079 @default.
• W2022143119 cites W1992789370 @default.
• W2022143119 cites W2001821405 @default.
• W2022143119 cites W2006143607 @default.
• W2022143119 cites W2014574137 @default.
• W2022143119 cites W2023634223 @default.
• W2022143119 cites W2026544037 @default.
• W2022143119 cites W2028046989 @default.
• W2022143119 cites W2029739208 @default.
• W2022143119 cites W2030282697 @default.
• W2022143119 cites W2033763265 @default.
• W2022143119 cites W2034052955 @default.
• W2022143119 cites W2038270610 @default.
• W2022143119 cites W2041511592 @default.
• W2022143119 cites W2048489884 @default.
• W2022143119 cites W2056312910 @default.
• W2022143119 cites W2062140760 @default.
• W2022143119 cites W2062294413 @default.
• W2022143119 cites W2062346797 @default.
• W2022143119 cites W2069007145 @default.
• W2022143119 cites W2082347869 @default.
• W2022143119 cites W2093539486 @default.
• W2022143119 cites W2094422818 @default.
• W2022143119 cites W2105556644 @default.
• W2022143119 cites W2114144373 @default.
• W2022143119 cites W2114280375 @default.
• W2022143119 cites W2114570899 @default.
• W2022143119 cites W2122309805 @default.
• W2022143119 cites W2127538271 @default.
• W2022143119 cites W2128203138 @default.
• W2022143119 cites W2145619229 @default.
• W2022143119 cites W27590684 @default.
• W2022143119 cites W4211217520 @default.
• W2022143119 cites W4231620004 @default.
• W2022143119 doi "https://doi.org/10.1016/j.bbi.2011.08.006" @default.
• W2022143119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21893187" @default.
• W2022143119 hasPublicationYear "2012" @default.
• W2022143119 type Work @default.
• W2022143119 sameAs 2022143119 @default.
• W2022143119 citedByCount "12" @default.
• W2022143119 countsByYear W20221431192012 @default.
• W2022143119 countsByYear W20221431192013 @default.
• W2022143119 countsByYear W20221431192014 @default.
• W2022143119 countsByYear W20221431192015 @default.
• W2022143119 countsByYear W20221431192016 @default.
• W2022143119 countsByYear W20221431192017 @default.
• W2022143119 countsByYear W20221431192018 @default.
• W2022143119 crossrefType "journal-article" @default.
• W2022143119 hasAuthorship W2022143119A5033720615 @default.
• W2022143119 hasAuthorship W2022143119A5040373664 @default.
• W2022143119 hasAuthorship W2022143119A5041641869 @default.
• W2022143119 hasAuthorship W2022143119A5054903943 @default.
• W2022143119 hasConcept C104317684 @default.
• W2022143119 hasConcept C125370674 @default.
• W2022143119 hasConcept C136449434 @default.
• W2022143119 hasConcept C14036430 @default.
• W2022143119 hasConcept C150194340 @default.
• W2022143119 hasConcept C169760540 @default.
• W2022143119 hasConcept C203014093 @default.
• W2022143119 hasConcept C2779341262 @default.
• W2022143119 hasConcept C2780931953 @default.
• W2022143119 hasConcept C54355233 @default.
• W2022143119 hasConcept C86803240 @default.
• W2022143119 hasConcept C8891405 @default.
• W2022143119 hasConceptScore W2022143119C104317684 @default.
• W2022143119 hasConceptScore W2022143119C125370674 @default.
• W2022143119 hasConceptScore W2022143119C136449434 @default.
• W2022143119 hasConceptScore W2022143119C14036430 @default.
• W2022143119 hasConceptScore W2022143119C150194340 @default.
• W2022143119 hasConceptScore W2022143119C169760540 @default.
• W2022143119 hasConceptScore W2022143119C203014093 @default.
• W2022143119 hasConceptScore W2022143119C2779341262 @default.
• W2022143119 hasConceptScore W2022143119C2780931953 @default.
• W2022143119 hasConceptScore W2022143119C54355233 @default.
• W2022143119 hasConceptScore W2022143119C86803240 @default.
• W2022143119 hasConceptScore W2022143119C8891405 @default.
• W2022143119 hasIssue "1" @default.
• W2022143119 hasLocation W20221431191 @default.
• W2022143119 hasLocation W20221431192 @default.
• W2022143119 hasOpenAccess W2022143119 @default.
• W2022143119 hasPrimaryLocation W20221431191 @default.
• W2022143119 hasRelatedWork W1976100129 @default.
• W2022143119 hasRelatedWork W2009966535 @default.
• W2022143119 hasRelatedWork W2036107469 @default.
• W2022143119 hasRelatedWork W2081358646 @default.

• next