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- W2022143565 abstract "The ARF transcript produces two proteins, the full-length ARF, p19ARF, and a short mitochondrial version, smARF. To explore the functional difference between the two, we generated GFP-fused expression vectors for each protein and introduced them into NIH3T3 murine fibroblasts, which sustains a global deletion in the INK4a locus but contains a functional p53 gene. GFP-p19ARF was located within the nucleolus as previously reported, whereas GFP-smARF was detected mainly in the nucleoplasm. GFP-smARF induced cell death although to a slightly lesser extent than p19ARF. GFP-smARF stabilized p53 thereby inducing expression of the target genes, MDM2 and p21. We suggest that smARF has functions other than mitochondria-mediated autophagy, and induces p53 expression and cell death via a novel mechanism." @default.
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- W2022143565 date "2008-07-01" @default.
- W2022143565 modified "2023-09-27" @default.
- W2022143565 title "The role of alterations in BRCA1, BRCA2, TP53 and ATM genes in sporadic breast tumors" @default.
- W2022143565 doi "https://doi.org/10.1016/s1359-6349(08)71623-9" @default.
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