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- W202214407 abstract "Kinetic proofreading is an intrinsic property of the cell signaling process. It arises as a consequence of the multiple interactions that occur after a ligand triggers a receptor to initiate a ignaling cascade and it ensures that false signals do not propagate to completion. In order for an active signaling complex to form after a ligand binds to a cell surface receptor, a sequence of binding and phosphorylation events must occur that are rapidly reversed if the ligand dissociates from the receptor. This gives rise to a mechanism by which cells can discriminate among ligands that bind to the same receptor but form ligand-receptor complexes with different lifetimes. We review experiments designed to test for kinetic proofreading and models that exhibit kinetic proofreading." @default.
- W202214407 created "2016-06-24" @default.
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- W202214407 date "2008-12-16" @default.
- W202214407 modified "2023-09-27" @default.
- W202214407 title "Kinetic Proofreading Model" @default.
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- W202214407 doi "https://doi.org/10.1007/978-0-387-09789-3_8" @default.
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