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- W2022144327 abstract "It is commonly believed that the tetrameric Adair constants for oxygen binding to human hemoglobin can be evaluated from a single oxygenation experiment at 'high' hemoglobin concentration without considering the consequence of the presence of alpha beta dimers. We present examples which demonstrate that this is a very dangerous assumption. Without a knowledge of the complete oxygenation-linked dimer-tetramer association reaction (alpha beta Xi----(alpha beta)2Xj), it is impossible to predict a priori how high of a hemoglobin concentration would be required to make this assumption. Furthermore, without a knowledge of the complete oxygenation-linked dimer-tetramer association reaction, it is impossible to predict a priori the direction and magnitude of the systematic errors which are induced by making this assumption." @default.
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- W2022144327 date "1990-08-01" @default.
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- W2022144327 title "Consequences of neglecting the hemoglobin concentration on the determination of Adair binding constants" @default.
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- W2022144327 doi "https://doi.org/10.1016/0301-4622(90)88022-k" @default.
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