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• W2022145302 abstract "Gabapentin (GBP) is a cyclic γ-aminobutyric acid (GABA) analog and investigational antiepileptic drug which is effective in the treatment of a variety of human and experimental seizures. GBP's antiepileptic mechanism of action is not known. The present studies tested for effects of GBP on inhibitory (GABA and glycine) and excitatory (N-methyl-d-aspartate (NMDA) and non-NMDA) amino acid neurotransmitter receptors, on repetitive firing of sodium (Na+) action potentials, and on voltage-dependent calcium (Ca2+) channel currents in cultured rodent neurons using intracellular, whole cell, or single channel recording techniques. GBP did not have a significant effect in any experiment when tested at or above concentrations that are therapeutic in humans except for a variable enhancement of NMDA-evoked depolarizations. These results suggest that the antiepileptic activity of GBP is not due to direct effects at receptors for inhibitory or excitatory amino acids or on voltage-dependent Na+ or Ca2+ channels." @default.
• W2022145302 created "2016-06-24" @default.
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• W2022145302 date "1993-10-01" @default.
• W2022145302 modified "2023-10-18" @default.
• W2022145302 title "Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons" @default.
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• W2022145302 doi "https://doi.org/10.1016/0920-1211(93)90023-z" @default.
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