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• W2022145688 abstract "The alpha4beta7 integrin has been shown to serve as a coreceptor for HIV. One anti-alpha4 integrin agent (natalizumab) has been approved for the treatment of multiple sclerosis and Crohn's disease. We found that activation of CD4+ T cells with retinoic acid induced the upregulation of alpha4 and beta7 integrins. However, natalizumab failed to block the replication of HIV-1 strains in lymphoid MT-4 cells or CD4+ T cells at concentrations up to 125 μg/ml. Our results suggest that alpha4 integrins are not essential cofactors for HIV replication." @default.
• W2022145688 created "2016-06-24" @default.
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• W2022145688 date "2009-01-14" @default.
• W2022145688 modified "2023-10-18" @default.
• W2022145688 title "Evaluation of the anti-HIV activity of natalizumab, an antibody against integrin alpha4" @default.
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• W2022145688 doi "https://doi.org/10.1097/qad.0b013e328320a7f8" @default.
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