Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022145881> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2022145881 endingPage "859" @default.
- W2022145881 startingPage "855" @default.
- W2022145881 abstract "The purpose of our study was to investigate the (auto)antibody repertoire of human tonsil B cells. To this end, unseparated tonsil B cells and “large” and “small” tonsil B cells, obtained after fractionation on a discontinuous Percoll gradient, were fused with the (human × mouse) heterohybridoma K6H6/B5. The IgM antibodies secreted by individual clones were analyzed in spot-enzyme-linked immunosorbent assay for reactivity against a panel of 5 autoantigens and 1 xenoantigen. The results show that both “mono-” and “multispecific” (auto)antibody-secreting clones can be obtained by somatic hybridization of unseparated, “small” and “large” tonsil B cells. The patterns of IgM reactivities in these three collections of hybridomas did not differ significantly. Inhibition experiments revealed that “multispecific” antibodies can bind with high affinity to more than one (auto)antigen. The results of these experiments are discussed in relation to the state of activation of tonsil B lymphocytes." @default.
- W2022145881 created "2016-06-24" @default.
- W2022145881 creator A5032942149 @default.
- W2022145881 creator A5065760562 @default.
- W2022145881 creator A5079891331 @default.
- W2022145881 creator A5085208309 @default.
- W2022145881 date "1987-01-01" @default.
- W2022145881 modified "2023-09-25" @default.
- W2022145881 title "Analysis of the human tonsil B cell repertoire by somatic hybridization: occurrence of both “monospecific” and “multispecific” (auto)antibody-secreting cells" @default.
- W2022145881 cites W1918956394 @default.
- W2022145881 cites W1966411902 @default.
- W2022145881 cites W1978717574 @default.
- W2022145881 cites W2001863306 @default.
- W2022145881 cites W2008603863 @default.
- W2022145881 cites W2010586398 @default.
- W2022145881 cites W2010664601 @default.
- W2022145881 cites W2011825464 @default.
- W2022145881 cites W2035093315 @default.
- W2022145881 cites W2040619664 @default.
- W2022145881 cites W2045513702 @default.
- W2022145881 cites W2048469310 @default.
- W2022145881 cites W2079769743 @default.
- W2022145881 cites W2082056686 @default.
- W2022145881 cites W2084833645 @default.
- W2022145881 cites W2086484085 @default.
- W2022145881 cites W2089276240 @default.
- W2022145881 cites W2091609495 @default.
- W2022145881 cites W2095433933 @default.
- W2022145881 cites W2095741007 @default.
- W2022145881 cites W2160209304 @default.
- W2022145881 doi "https://doi.org/10.1002/eji.1830170619" @default.
- W2022145881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3496225" @default.
- W2022145881 hasPublicationYear "1987" @default.
- W2022145881 type Work @default.
- W2022145881 sameAs 2022145881 @default.
- W2022145881 citedByCount "24" @default.
- W2022145881 crossrefType "journal-article" @default.
- W2022145881 hasAuthorship W2022145881A5032942149 @default.
- W2022145881 hasAuthorship W2022145881A5065760562 @default.
- W2022145881 hasAuthorship W2022145881A5079891331 @default.
- W2022145881 hasAuthorship W2022145881A5085208309 @default.
- W2022145881 hasConcept C104317684 @default.
- W2022145881 hasConcept C134305767 @default.
- W2022145881 hasConcept C147483822 @default.
- W2022145881 hasConcept C153911025 @default.
- W2022145881 hasConcept C159654299 @default.
- W2022145881 hasConcept C202751555 @default.
- W2022145881 hasConcept C203014093 @default.
- W2022145881 hasConcept C2778453870 @default.
- W2022145881 hasConcept C2779419017 @default.
- W2022145881 hasConcept C48679268 @default.
- W2022145881 hasConcept C54355233 @default.
- W2022145881 hasConcept C86803240 @default.
- W2022145881 hasConceptScore W2022145881C104317684 @default.
- W2022145881 hasConceptScore W2022145881C134305767 @default.
- W2022145881 hasConceptScore W2022145881C147483822 @default.
- W2022145881 hasConceptScore W2022145881C153911025 @default.
- W2022145881 hasConceptScore W2022145881C159654299 @default.
- W2022145881 hasConceptScore W2022145881C202751555 @default.
- W2022145881 hasConceptScore W2022145881C203014093 @default.
- W2022145881 hasConceptScore W2022145881C2778453870 @default.
- W2022145881 hasConceptScore W2022145881C2779419017 @default.
- W2022145881 hasConceptScore W2022145881C48679268 @default.
- W2022145881 hasConceptScore W2022145881C54355233 @default.
- W2022145881 hasConceptScore W2022145881C86803240 @default.
- W2022145881 hasIssue "6" @default.
- W2022145881 hasLocation W20221458811 @default.
- W2022145881 hasLocation W20221458812 @default.
- W2022145881 hasOpenAccess W2022145881 @default.
- W2022145881 hasPrimaryLocation W20221458811 @default.
- W2022145881 hasRelatedWork W1529369993 @default.
- W2022145881 hasRelatedWork W1624608897 @default.
- W2022145881 hasRelatedWork W1973692620 @default.
- W2022145881 hasRelatedWork W1977030608 @default.
- W2022145881 hasRelatedWork W1977987728 @default.
- W2022145881 hasRelatedWork W2040191638 @default.
- W2022145881 hasRelatedWork W2107679548 @default.
- W2022145881 hasRelatedWork W2146472642 @default.
- W2022145881 hasRelatedWork W4322149202 @default.
- W2022145881 hasRelatedWork W940191291 @default.
- W2022145881 hasVolume "17" @default.
- W2022145881 isParatext "false" @default.
- W2022145881 isRetracted "false" @default.
- W2022145881 magId "2022145881" @default.
- W2022145881 workType "article" @default.