FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022145965> ?p ?o ?g. }

• W2022145965 endingPage "1591" @default.
• W2022145965 startingPage "1580" @default.
• W2022145965 abstract "Dual action antidepressants have important therapeutic implications. Methylene blue (MB), a charged compound structurally related to tricyclic antidepressants, acts on both monoamine oxidase (MAO) and the nitric oxide (NO)-cGMP pathway, and has demonstrated antidepressant activity in rodents. We investigated the antidepressant properties of MB and selected structural analogues and whether their actions involve MAO, NO synthase (NOS) and regional brain monoamines. Acute imipramine (IMI, 15 mg/kg), saline, MB, acriflavine (ACR), methylene green (MG), methylene violet (MV), thionine (THI) and tacrine (TAC) (1-60 mg/kg i.p.) were tested for antidepressant activity in the forced swim test (FST), as well as MAO-A/B inhibitory activity. Active antidepressant compounds were subsequently studied at their most effective dose during sub-chronic treatment, followed by behavioural sampling in the FST and assay of cortico-limbic monoamines and hippocampal nitrate (for NOS activity). Only IMI, MB (15, 30, 60 mg/kg) and MG (7.5, 25, 40 mg/kg) reduced immobility in the acute FST. MB, MG and ACR were potent inhibitors of especially MAO-A. Following sub-chronic treatment, IMI (15 mg/kg) increased noradrenergic behaviour in the FST, while MB (15 mg/kg) and MG (15 mg/kg) enhanced serotonergic behaviour. MB and MG bolstered cortico-limbic serotonin (5HT) levels and to a lesser extent l-norepinephrine (l-NE), but did not significantly alter regional dopamine (DA) levels. MB, and to lesser degree MG, reduced hippocampal nitrate levels. MB and MG present with structure-specific antidepressant-like effects following acute and sub-chronic treatment, possibly involving NOS and MAO-A inhibition and cortico-limbic 5HT and l-NE release. A role for MAO-B and DA appears minimal." @default.
• W2022145965 created "2016-06-24" @default.
• W2022145965 creator A5003210816 @default.
• W2022145965 creator A5009009533 @default.
• W2022145965 creator A5012173155 @default.
• W2022145965 creator A5022879952 @default.
• W2022145965 creator A5030341813 @default.
• W2022145965 creator A5030450621 @default.
• W2022145965 creator A5071317218 @default.
• W2022145965 creator A5085048867 @default.
• W2022145965 date "2010-11-01" @default.
• W2022145965 modified "2023-09-26" @default.
• W2022145965 title "Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues" @default.
• W2022145965 cites W109954717 @default.
• W2022145965 cites W1584046157 @default.
• W2022145965 cites W190813598 @default.
• W2022145965 cites W1928975456 @default.
• W2022145965 cites W1969852349 @default.
• W2022145965 cites W1973386992 @default.
• W2022145965 cites W1976740393 @default.
• W2022145965 cites W1981363848 @default.
• W2022145965 cites W1984771558 @default.
• W2022145965 cites W1986211748 @default.
• W2022145965 cites W1986875797 @default.
• W2022145965 cites W1988331289 @default.
• W2022145965 cites W1991412103 @default.
• W2022145965 cites W1999214302 @default.
• W2022145965 cites W2000350197 @default.
• W2022145965 cites W2001092446 @default.
• W2022145965 cites W2003414772 @default.
• W2022145965 cites W2006014108 @default.
• W2022145965 cites W2015389516 @default.
• W2022145965 cites W2016336988 @default.
• W2022145965 cites W2017546704 @default.
• W2022145965 cites W2018303025 @default.
• W2022145965 cites W2023414423 @default.
• W2022145965 cites W2027874441 @default.
• W2022145965 cites W2028980996 @default.
• W2022145965 cites W2029585417 @default.
• W2022145965 cites W2031843542 @default.
• W2022145965 cites W2033146497 @default.
• W2022145965 cites W2036217770 @default.
• W2022145965 cites W2040268792 @default.
• W2022145965 cites W2042825148 @default.
• W2022145965 cites W2045144396 @default.
• W2022145965 cites W2048557710 @default.
• W2022145965 cites W2051360846 @default.
• W2022145965 cites W2053472601 @default.
• W2022145965 cites W2054149684 @default.
• W2022145965 cites W2056152146 @default.
• W2022145965 cites W2057802026 @default.
• W2022145965 cites W2058105012 @default.
• W2022145965 cites W2060006930 @default.
• W2022145965 cites W2060997087 @default.
• W2022145965 cites W2062178630 @default.
• W2022145965 cites W2063544942 @default.
• W2022145965 cites W2074938907 @default.
• W2022145965 cites W2081884263 @default.
• W2022145965 cites W2082849648 @default.
• W2022145965 cites W2105492939 @default.
• W2022145965 cites W2106623141 @default.
• W2022145965 cites W2110914496 @default.
• W2022145965 cites W2112063066 @default.
• W2022145965 cites W2118826874 @default.
• W2022145965 cites W2131167630 @default.
• W2022145965 cites W2157813209 @default.
• W2022145965 cites W2159979884 @default.
• W2022145965 cites W2160750591 @default.
• W2022145965 cites W2163215067 @default.
• W2022145965 cites W2170684975 @default.
• W2022145965 cites W2172527495 @default.
• W2022145965 cites W2214256977 @default.
• W2022145965 cites W2949118495 @default.
• W2022145965 cites W67849762 @default.
• W2022145965 doi "https://doi.org/10.1016/j.bcp.2010.07.037" @default.
• W2022145965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20699087" @default.
• W2022145965 hasPublicationYear "2010" @default.
• W2022145965 type Work @default.
• W2022145965 sameAs 2022145965 @default.
• W2022145965 citedByCount "64" @default.
• W2022145965 countsByYear W20221459652012 @default.
• W2022145965 countsByYear W20221459652013 @default.
• W2022145965 countsByYear W20221459652014 @default.
• W2022145965 countsByYear W20221459652015 @default.
• W2022145965 countsByYear W20221459652016 @default.
• W2022145965 countsByYear W20221459652017 @default.
• W2022145965 countsByYear W20221459652018 @default.
• W2022145965 countsByYear W20221459652019 @default.
• W2022145965 countsByYear W20221459652020 @default.
• W2022145965 countsByYear W20221459652021 @default.
• W2022145965 countsByYear W20221459652022 @default.
• W2022145965 countsByYear W20221459652023 @default.
• W2022145965 crossrefType "journal-article" @default.
• W2022145965 hasAuthorship W2022145965A5003210816 @default.
• W2022145965 hasAuthorship W2022145965A5009009533 @default.
• W2022145965 hasAuthorship W2022145965A5012173155 @default.
• W2022145965 hasAuthorship W2022145965A5022879952 @default.
• W2022145965 hasAuthorship W2022145965A5030341813 @default.

• next