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- W2022146148 abstract "Exit from the cell cycle requires the downregulation of Cyclin/Cdk activity. In the ovary of Drosophila, Encore activity is necessary in the germline to exit the division program after four mitotic divisions. We find that in encore mutant germaria, Cyclin A persists longer than in wild type. In addition, Cyclin E expression is not downregulated after the fourth mitosis and accumulates in a polyubiquitinated form. Mutations in genes coding for components of the SCF pathway such as cul1, UbcD2 and effete enhance the extra division phenotype of encore. We show that Encore physically interacts with the proteasome, Cul1 and Cyclin E. The association of Cul1, phosphorylated Cyclin E and the proteasome 19S-RP subunit S1 with the fusome is affected in encore mutant germaria. We propose that in encore mutant germaria the proteolysis machinery is less efficient and, in addition, reduced association of Cul1 and S1 with the fusome may compromise Cyclin E destruction and consequently promote an extra round of mitosis." @default.
- W2022146148 created "2016-06-24" @default.
- W2022146148 creator A5049503424 @default.
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- W2022146148 date "2003-12-22" @default.
- W2022146148 modified "2023-10-11" @default.
- W2022146148 title "Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis during <i>Drosophila</i> oogenesis" @default.
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- W2022146148 doi "https://doi.org/10.1242/dev.00855" @default.
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