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- W2022146871 abstract "The aim of this study was to investigate the drug-loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2 % w/w scleroglucan gel matrix loaded with 0, 0.02, 0.04, 0.06, 0.2 and 0.4 % w/w of theophylline (Th, used as a model drug) were investigated. Rheological measurements were performed in a controlled-stress rotational-shear rheometer under isothermal conditions. For theophylline release from the gel a flat Franz cell was used and the kinetic parameters were derived applying a semi-empirical power law. The influence of scleroglucan molar weight on kinetic and rheological behaviour was also studied. Results suggest two possible effects of drug loading on the gel network: in the 0.04–0.06 % w/w Th range a plasticizing effect and in the 0.2–0.4 % w/w Th range a rigidization effect. In the first range mentioned, the changes in the gel structural properties tested by means of rheological measurements are coincident with changes in drug-release kinetics. Copyright © 2005 Society of Chemical Industry" @default.
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- W2022146871 date "2005-12-01" @default.
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- W2022146871 title "Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings" @default.
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- W2022146871 doi "https://doi.org/10.1002/pi.1889" @default.
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