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- W2022146949 abstract "Abstract In previous studies, we demonstrated that intestinal epithelial cells of the mouse small intestine could present exogenous antigen to specific CD4 + T cell hybridomas. We now report on the abililty of normal enterocytes to present the self superantigen M1sl a . Enterocytes from M1sl a but not from M1sl b strains stimulated interleukin‐2 production through aVβ6 + T cell hybridoma specific for M1sl a determinants. Antibody inhibition experiments showed that enterocytes presented M is determinants via a major histocompatibility complex class II‐dependent mechanism. Furthermore, the ability of enterocytes to activate Vβ6 + M1sl a ‐specific T cells was inhibited by monoclonal antibodies against the Orf protein encoded by an Mtv‐7 provirus which is associated with M1sl a expression. These findings provide evidence for the first time that M is determinants are expressed on normal enterocytes and support the theory of a possible role of these cells in extrathymic selection of T cell receptor Vβ repertoire of intraepithelial T lymphocytes." @default.
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- W2022146949 date "1993-10-01" @default.
- W2022146949 modified "2023-09-27" @default.
- W2022146949 title "Mouse intestinal epithelial cells express the self superantigen Mis1" @default.
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- W2022146949 doi "https://doi.org/10.1002/eji.1830231053" @default.
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