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- W2022147361 abstract "Abstract Background Ultrasound imaging has been recognised as a non-invasive, reproducible method for assessing the major salivary glands. The aim of this study was to investigate the relation between ultrasound imaging of major glands and focal lymphocytic score (FS) of minor salivary glands in Sjogren's syndrome. Methods Biopsies of labial glands and ultrasound imaging of major glands were done on 196 patients (mean age 55 years, 19 male, 177 female) attending the Sjogren's Clinic at Guy's Hospital. FS of labial glands was judged by two histopathologists whose assessment was standardised. Ultrasonography was done with a single Philips-iU22 Ultrasound machine, and a disease severity score (US) was determined. Patients were categorised into three groups: those diagnosed with Sjogren's syndrome according to the American-European classification criteria (Sjogren's syndrome group), those with non-specific sialadenitis (sialadenitis group), and those with normal biopsy results (non-salivary gland disease group). Findings There was a highly significant correlation between FS and US scores (mean score 1·8 [SD 2·4, range 0–11·3] vs 2·7 [2·9, 0–9], r =0·665, n=196; p vs 5·0 [2·4, 0–9], r =0·395, n=87; p vs 1·1 [1·7, 0–7], r =0·321, n=66; p vs 0·5 [SD 1·2, 0–5], n=43). Interpretation This is the first large-scale study to show the strong relation between US scores of major salivary glands, and FS scores of minor salivary glands, suggesting a uniform disease process. Ultrasound analysis proves to be an important methodology in management and studies of Sjogren's syndrome. Funding National Institute for Health Research." @default.
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- W2022147361 date "2013-02-01" @default.
- W2022147361 modified "2023-09-25" @default.
- W2022147361 title "Correlation between ultrasound imaging of major salivary glands and histopathological findings of labial gland biopsy samples in Sjogren's syndrome" @default.
- W2022147361 doi "https://doi.org/10.1016/s0140-6736(13)60459-6" @default.
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