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- W2022148626 endingPage "559" @default.
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- W2022148626 abstract "Brownian dynamics methodology was applied to simulate the encounter of aminoglycosidic antibiotics with the ribosomal A-site RNA. Studied antibiotics included neamine, neomycin, ribostamycin and paromomycin which differ in chemical structure, the number of pseudo-sugar rings and the net charge. The influence of structural, electrostatic and hydrodynamic properties of antibiotics on the kinetics of their association with the ribosomal A-site was analyzed. The computed diffusion limited rates of association are of the order of 10(10)[Formula: see text] and they weakly depend on ionic strength. Prior to binding antibiotics often slide along the RNA groove with the time scale of approximately 10 ns per base pair in case of neamine. We observed that upon forming the encounter complex aminoglycosides displace from the binding pocket up to two Mg(2+) ions." @default.
- W2022148626 created "2016-06-24" @default.
- W2022148626 creator A5045570505 @default.
- W2022148626 creator A5080875748 @default.
- W2022148626 creator A5088500200 @default.
- W2022148626 date "2008-03-06" @default.
- W2022148626 modified "2023-10-10" @default.
- W2022148626 title "Association of Aminoglycosidic Antibiotics with the Ribosomal A-Site Studied with Brownian Dynamics" @default.
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- W2022148626 doi "https://doi.org/10.1021/ct700210n" @default.
- W2022148626 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2612597" @default.
- W2022148626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19343095" @default.
- W2022148626 hasPublicationYear "2008" @default.
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